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首页> 外文期刊>Annual Review of Immunology >Determinants of lymphoid-myeloid lineage diversification.
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Determinants of lymphoid-myeloid lineage diversification.

机译：淋巴样髓系谱系多样化的决定因素。

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In recent years, investigators have made great progress in delineating developmental pathways of several lymphoid and myeloid lineages and in identifying transcription factors that establish and maintain their fate. However, the developmental branching points between these two large cell compartments are still controversial, and little is known about how their diversification is induced. Here, we give an overview of determinants that play a role at lymphoid-myeloid junctures, in particular transcription factors and cytokine receptors. Experiments showing that myeloid lineages can be reversibly reprogrammed into one another by transcription factor network perturbations are used to highlight key principles of lineage commitment. We also discuss experiments showing that lymphoid-to-myeloid but not myeloid-to-lymphoid conversions can be induced by the enforced expression of a single transcription factor. We close by proposing that this asymmetry is related to a higher complexity of transcription factor networks in lymphoid cells compared with myeloid cells, and we suggest that this feature must be considered when searching for mechanisms by which hematopoietic stem cells become committed to lymphoid lineages.
机译：近年来，研究人员在描绘几种淋巴和髓系的发育途径以及鉴定建立和维持其命运的转录因子方面取得了巨大进展。但是，这两个大细胞区室之间的发育分支点仍存在争议，关于如何诱导其多样化知之甚少。在这里，我们概述了在淋巴样髓系连接处起作用的决定簇，特别是转录因子和细胞因子受体。实验表明，通过转录因子网络扰动可将髓系谱系可逆地重新编程为彼此，这些实验被用来强调谱系承诺的关键原理。我们还讨论了实验，这些实验表明，单个转录因子的强制表达可以诱导淋巴样到髓样的转化，而不是髓样到淋巴样的转化。最后，我们提出这种不对称性与髓样细胞相比，淋巴样细胞中转录因子网络的复杂性更高，我们建议在寻找造血干细胞成为淋巴样谱系的机制时必须考虑这一特征。

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