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首页> 外文期刊>Annual Review of Immunology >The tortuous journey of a biochemist to immunoland and what he found there.
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The tortuous journey of a biochemist to immunoland and what he found there.

机译：生物化学家到免疫土地的曲折旅程以及他在那发现的东西。

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After starting out to become a physician, by a series of accidents I found myself at NIH in 1951 during its most productive growth phase. At age 26, I had a fully funded, independent laboratory and did not know what to work on. With advice from colleagues, I initiated a study of how penicillin kills bacteria. Twenty years later, my lab had outlined the structure and biosynthesis of the peptidoglycan of bacterial cell walls and had discovered that penicillin inhibited the terminal step in its biosynthesis catalyzed by transpeptidases. I then switched fields, moving to Harvard in 1968 and beginning the study of human HLA proteins. Twenty-five years later, the last half of which was spent in a stimulating collaboration with the late Don Wiley, our labs had isolated, crystallized, and elucidated the three-dimensional structures of these molecules and shown that their principal function was to present peptides to the immune system in initiating an immune response. More recently, the laboratory has focused on natural killer cells and their roles in peripheral blood and in the pregnant uterine decidua. It has been a wonderful scientific journey.
机译：在开始成为医生之后，由于一系列事故，我于1951年进入NIH，当时它处于生产力最高的成长阶段。在26岁的时候，我有一个资金雄厚的独立实验室，不知道该做什么。在同事的建议下，我开始研究青霉素如何杀死细菌。二十年后，我的实验室概述了细菌细胞壁肽聚糖的结构和生物合成，并发现青霉素抑制了转肽酶催化的生物合成中的末端步骤。然后我切换了领域，于1968年移居哈佛，开始研究人类HLA蛋白。 25年后，其中的后半部分花在了与已故的唐·威利（Don Wiley）的刺激性合作中，我们的实验室已经分离，结晶并阐明了这些分子的三维结构，并表明它们的主要功能是呈递肽引发免疫反应的过程。最近，实验室致力于自然杀伤细胞及其在外周血和妊娠子宫蜕膜中的作用。这是一次美妙的科学旅程。

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