Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization

Alireza Shalviri; Qiang Liu; Mohammad J. Abdekhodaie

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Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization

机译：Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization

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This work was intended to develop a new cross-linked gelatinized starch-xanthan gum hydrogel system, to characterize the properties of the new material, and to explore its potential applications in controlled drug delivery. Cross-linked starch-xanthan gum polymers were synthesized with varying levels of xan-than gum and sodium trimetaphosphate (STMP). The reaction of starch-xanthan gum polymers with STMP was examined using solid ~(31)P NMR spectroscopy and FTIR. Morphology of the films made from the new polymers was studied by scanning electron microscopy. The swelling properties and the network parameters such as gel mesh size of the films were investigated. The permeation of solutes with various molecular weights and charges across the films was determined. ~(31)P NMR and FTIR spectra showed that both starch and xanthan gum were reacted with STMP. The swelling ratio of the films was higher at higher STMP and xanthan gum levels. The gel mesh size increased with increasing swelling ratio varying from 2.84 to 6.74 nm. Permeability of anionic drugs across the polymeric films was significantly lower than their neutral form due mainly to the electrostatic repulsion between the negatively charged drugs and the polymer. The results suggest that the new cross-linked starch-xanthan gum hydrogels can be potentially used as a film-forming material in controlled release formulations.

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来源
《Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides》 |2010年第4期|898-907|共10页
作者
Alireza Shalviri; Qiang Liu; Mohammad J. Abdekhodaie;
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作者单位

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada M5S 3M2;

Guelph Food Research Center, Agriculture and Agri-food Canada, Guelph, ON, Canada N1G 5C9;

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正文语种英语
中图分类天然化合物;
关键词
Starch-xanthan gum hydrogels; Characterization of cross-links; Equilibrium swelling; Gel mesh size; Solute permeability; Effect of charge and molecular size;

Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization

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