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首页> 外文期刊>In vivo. >Intraarterial hepatic chemoembolization of liver metastases from colorectal cancer adopting irinotecan-eluting beads: results of a phase II clinical study.
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Intraarterial hepatic chemoembolization of liver metastases from colorectal cancer adopting irinotecan-eluting beads: results of a phase II clinical study.

机译：采用伊立替康洗脱珠的大肠癌肝转移的肝内动脉化疗栓塞：II期临床研究的结果。

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Since November 2005 a clinical trial of intraarterial hepatic chemoembolization (TACE) with irinotecan-eluting beads has been ongoing in 20 patients affected by liver metastases from colorectal cancer in a palliative setting. A high response rate (80%), with reduction of lesional contrast enhancement in all responding patients was found. The procedure was well tolerated by most patients, with a median duration of hospitalization of 3 days (range 1-10 days). The most important adverse event was abdominal pain during the injection. Adequate supportive treatment with antibiotic and antiemetic prophylaxis, dexamethasone, and intravenous hydration is strictly necessary until the serum levels of transaminases are stabilized and in order to prevent infections. Major analgesics such as morphine must be used before and after the procedure. Our results suggest that TACE using irinotecan-eluting beads is feasible and active in pretreated patients with liver metastases from CRC.
机译：自2005年11月以来，一项针对具有伊立替康洗脱珠的动脉内肝化学栓塞（TACE）的临床试验已在20例姑息性结肠直肠癌肝转移患者中进行。发现所有应答患者的应答率均很高（80％），而病灶对比增强却有所降低。大多数患者对该手术耐受良好，平均住院时间为3天（1-10天）。最重要的不良事件是注射期间的腹痛。严格需要用抗生素和止吐药，地塞米松和静脉内水合作用充分的支持治疗，直到转氨酶的血清水平稳定并预防感染为止。手术前后必须使用吗啡等主要止痛药。我们的研究结果表明，使用伊立替康洗脱珠进行TACE在经CRC治疗的肝转移患者中是可行且有效的。

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