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首页> 外文期刊>Indian Journal of Experimental Biology >Antitumor potential of Castanopsis indica (Roxb. ex Lindl.) A. DC. leaf extract against Ehrlich's ascites carcinoma cell
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Antitumor potential of Castanopsis indica (Roxb. ex Lindl.) A. DC. leaf extract against Ehrlich's ascites carcinoma cell

机译：米Cast的抗肿瘤潜力（Roxb。ex Lindl。）叶提取物抗艾氏腹水癌细胞

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摘要

Methanol extract of C. indica (MECI) leaves showed direct cytotoxicity on Ehrlich ascites carcinoma (EAC) cell in a dose dependant manner and there was significant decrease in the tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile and biochemical estimations were significantly restored to normal levels in MECI treated as compared to EAC control mice. MECI treatment significantly modulated the tissue antioxidant assay parameters as compared to the EAC control mice. The results revealed that MECI possesses significant dose dependent antitumor potential which may be due to its cytotoxicity and antioxidant properties.
机译：C树的甲醇提取物（MECI）对艾氏腹水癌（EAC）细胞表现出直接的细胞毒性，呈剂量依赖性，并且肿瘤体积，活细胞数，肿瘤重量显着减少，并且EAC肿瘤的寿命延长轴承小鼠。与EAC对照小鼠相比，MECI处理后的血液学特征和生化评估显着恢复至正常水平。与EAC对照小鼠相比，MECI处理可显着调节组织抗氧化剂测定参数。结果表明，MECI具有显着的剂量依赖性抗肿瘤潜力，这可能是由于其细胞毒性和抗氧化特性所致。

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