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首页> 外文期刊>Indian Journal of Experimental Biology >Endothelium-dependent and independent vasorelaxant effects of aqueous extract of Tridax procumbens Lin. leaf in rat aortic rings
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Endothelium-dependent and independent vasorelaxant effects of aqueous extract of Tridax procumbens Lin. leaf in rat aortic rings

机译：Tridax procumbens Lin的水提取物的内皮依赖性和独立血管舒张作用。大鼠主动脉环中的叶子

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摘要

Tridax procumbens leaf extract induced aortic relaxation in a concentration-dependent manner, for both phenylephrine (PE) and KC1- induced contractions in isolated rat aortic rings. The relaxation effect of the extract on PE-induced contractidn was 57% greater than that on KC1- induced contraction. The extract caused dose-dependent relaxations in precontracted isolated rat aorta with phenylephrine; the relaxation was attenuated by the removal of endothelium. However, the relaxation responses to sodium nitroprusside were not significantly abolished by the removal of endothelium. The vasorelaxatory effect of the extract was completely abolished in presence of L-NAME. The results indicate that the vasorelaxant effect of T. procumbens extract is probably mediated by both endothelium-dependent and-independent mechanisms.
机译：Tridax procumbens叶提取物对苯肾上腺素（PE）和KC1诱导的离体大鼠主动脉环的收缩均以浓度依赖性方式诱导主动脉舒张。提取物对PE诱导的收缩的松弛作用比对KC1诱导的收缩的松弛作用大57％。该提取物在预收缩的大鼠主动脉中与去氧肾上腺素引起剂量依赖性的舒张作用。通过去除内皮减弱了松弛。然而，通过去除内皮并没有明显消除对硝普钠的松弛反应。在存在L-NAME的情况下，提取物的血管舒张作用被完全消除。结果表明，刺柏提取物的血管舒张作用可能由内皮依赖性和非依赖性机制介导。

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