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首页> 外文期刊>American journal of human biology: the official journal of the Human Biology Council >A possible link between the pubertal growth of girls and ovarian cancer in their daughters.
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A possible link between the pubertal growth of girls and ovarian cancer in their daughters.

机译：女孩的青春期生长与女儿的卵巢癌之间可能存在联系。

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At puberty, the distance between the iliac crests of the female pelvis, measured by the intercristal and interspinous diameters, increases rapidly. This is mainly controlled by estrogens. We have followed up 6,370 women who were born in Helsinki during 1934-1944, and whose mothers' pelvic bones were measured during routine antenatal care. We have previously reported that women whose mothers had larger intercristal diameters had higher rates of breast cancer. We postulated that large intercristal diameters are markers of high circulating concentrations of estrogen, which are established at puberty, persist through reproductive life and cause genetic instability in differentiating breast cells in female embryos. We now report on ovarian cancer in the same cohort. Our hypothesis was that the risk of this cancer would also be higher in women whose mothers had broader hips. We found that, when compared with all other women, the hazard ratio for ovarian cancer was 3.3 (95% CI 1.6-7.0, P = 0.004) in the daughters of mothers whose interspinous diameter was greater than 27 cm. Among mothers who had an early menarche, each measure of broad hips was associated with increased risk of ovarian cancer in their daughters. We postulate that ovarian cancer is initiated by exposure of the fetal ovary to maternal sex hormones. Concentrations of these hormones may be higher in mothers who had an early menarche. The maternal sex hormone profile that initiates ovarian cancer may be the product of poor nutrition and growth in early childhood followed by catch-up pre-pubertal growth.
机译：在青春期，女性的骨盆的rest顶之间的距离（通过环间和棘突间直径测量）迅速增加。这主要是由雌激素控制的。我们追踪了1934-1944年在赫尔辛基出生的6370名妇女，这些妇女的母亲的骨盆骨是在常规产前检查中测量的。我们以前曾报道过，母亲间裂直径较大的女性患乳腺癌的几率更高。我们推测，大的间质直径是高浓度的雌激素的标志物，这种标志物在青春期就已确立，在生殖生命中持续存在，并在分化女性胚胎的乳腺细胞中引起遗传不稳定。现在，我们在同一队列中报告卵巢癌。我们的假设是，母亲臀部较宽的女性患这种癌症的风险也会更高。我们发现，与所有其他女性相比，在棘突间直径大于27 cm的母亲的女儿中，卵巢癌的危险比为3.3（95％CI 1.6-7.0，P = 0.004）。在初潮初潮的母亲中，每个臀部宽大的测量指标都与女儿患卵巢癌的风险增加有关。我们假设卵巢癌是由胎儿卵巢暴露于母体性激素引起的。在初潮早期的母亲中，这些激素的浓度可能更高。引发卵巢癌的母体性激素状况可能是儿童早期营养不良和生长发育不足，然后是追赶青春期前生长的产物。

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