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首页> 外文期刊>American journal of human biology: the official journal of the Human Biology Council >Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.
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Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.

机译：巴西人口样本的遗传组成基于一组28个祖先的信息性SNP。

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摘要

Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of F(st) among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations.
机译：祖先提供信息的SNP可用于估计个人和人口的生物地理血统。巴西人口的特征是三个亲代人口（欧洲，非洲和巴西土著美洲印第安人）的遗传背景，其混合方式广泛而多样。在这项工作中，我们使用三个亲代人口来源（非洲，美洲印第安人和欧洲），将28个祖先信息丰富的SNP的信息内容分析成多个面板，以推断五个巴西地缘政治区域的城市样本中的遗传混合。 SNP将亲代种群彼此分开，因此可以用于三个杂种混合种群的祖先估计。数据用于通过混合模型推断巴西人的遗传血统。对巴西五个地缘政治区域中F（st）的成对估计表明，仅南部地区与其余地区之间几乎没有遗传分化。祖先结果的估计与巴西人口的异质遗传特征相符，其中欧洲祖先的贡献很大（0.771），其次是非洲人的贡献（0.143）和美洲人的贡献（0.085）。所描述的多重SNP面板可能是生物人类学研究的有用工具，但在混合人群的遗传关联研究中控制杂散结果可能具有重要价值。

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