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首页> 外文期刊>American journal of human biology: the official journal of the Human Biology Council >Short-term secular variation in menarche and blood lead concentration in school girls in the copper basin of southwestern Poland: 1995 and 2007
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Short-term secular variation in menarche and blood lead concentration in school girls in the copper basin of southwestern Poland: 1995 and 2007

机译:波兰西南部铜盆地女学生初潮和血铅浓度的短期长期变化:1995年和2007年

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Objectives: To evaluate short-term secular change in menarche and associations with blood lead level in Polish girls between 1995 and 2007. Methods: Menarcheal status of school girls 7-16 years from villages in southwestern Poland was surveyed in 1995, 2001, 2004, and 2007. Blood lead was sampled in 1995 and 2007. Median ages and variance statistics for menarche were estimated with probit analysis. Associations between blood lead level and menarcheal status in 1995 and 2007 were analyzed with logistic regression using blood lead level as an independent binary variable: 2.00-5.00 and ≥5.10 μg/dl. Results: Median ages at menarche declined slightly from 1995 (13.36 ± 0.06 years) to 2001 (13.20 ± 0.04 years), was stable in 2004 (13.20 ± 0.05 years), and declined to 2007 (12.81 ± 0.05 years). Blood lead levels declined from 6.57 ± 0.13 μg/dl in 1995 to 4.24 ± 0.14 μg/dl in 2007. With age, height, and BMI controlled, probability of attaining menarche was not associated with blood lead in 1995, but was decreased with increased blood lead in 2007 (OR 0.31, 95% CI 0.09-1.06, P = 0.057). Conclusion: Ages at menarche and blood lead levels declined between 1995 and 2007. Higher blood lead levels were not associated with menarche in 1995, suggesting that nutritional and health conditions and perhaps somewhat unstable social and economic conditions in the 1980s and early 1990s may have masked the influence of lead on sexual maturation. Elevated blood lead was associated with the probability of later menarche in 2007, although the association was of borderline (P = 0.06).
机译:目的:评估1995年至2007年间波兰女童初潮的短期长期变化及其与血铅水平的关系。方法:1995、2001、2004年对波兰西南部村庄7-16岁女童的初潮状况进行了调查, 2007年和2007年。1995年和2007年对血铅进行了采样。初潮初潮的年龄中位数和方差统计量通过概率分析进行了估算。使用血铅水平作为独立的二元变量:2.00-5.00和≥5.10μg/ dl,通过逻辑回归分析了1995年和2007年血铅水平与月经初潮之间的关系。结果:初潮的中位年龄从1995年(13.36±0.06岁)到2001年(13.20±0.04岁)略有下降,在2004年(13.20±0.05岁)稳定,并下降到2007年(12.81±0.05岁)。血铅水平从1995年的6.57±0.13μg/ dl下降到2007年的4.24±0.14μg/ dl。受年龄,身高和BMI的控制,初潮的概率与血铅无关,但在1995年随着血铅的增加而降低。 2007年血铅(OR 0.31,95%CI 0.09-1.06,P = 0.057)。结论:1995年至2007年,初潮年龄和血铅水平下降。1995年,初潮年龄与血铅水平无关,这表明1980年代和1990年代初的营养和健康状况以及可能有些不稳定的社会和经济状况可能被掩盖了。铅对性成熟的影响。血铅升高与2007年以后初潮的可能性有关,尽管这种关联是临界的(P = 0.06)。

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