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首页> 外文期刊>Indian journal of pharmaceutical sciences. >In vitro release characteristics of matrix tablets: Study of Karaya gum and Guar gum as release modulators
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In vitro release characteristics of matrix tablets: Study of Karaya gum and Guar gum as release modulators

机译：基质片剂的体外释放特性：Karaya胶和瓜尔胶作为释放调节剂的研究

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摘要

Matrix tablets of phenylpropanolamine were fabricated using karaya gum and guar gum, alone or in combination with other excipients. The tablets were evaluated for physical characteristics like hardness, weight variation, friability, swelling index and drug content. In vitro release of drug was performed in 0.1N HCl (pH 1.2) for 2 h and the rest of dissolution in phosphate buffer (pH 6.8). The effect of water-soluble (lactose) and water-insoluble (dicalcium phosphate) excipients on drug release was evaluated. All the physical characteristics of the fabricated tablets were within acceptable limits. The tablets with karaya gum exhibited greater swelling indices than those with guar gum. All the batches provided drug release over a period of 6 h. The level of matrix former in the tablets affects drug release. Incorporation of lactose or dicalcium phosphate influenced drug release, but at lower polymer levels only. A combination of karaya gum and guar gum exhibited more sustained release than individual gum.
机译：单独或与其他赋形剂组合使用karaya胶和瓜尔豆胶制备苯基丙醇胺的基质片剂。评价片剂的物理特性，例如硬度，重量变化，易碎性，溶胀指数和药物含量。在0.1N HCl（pH 1.2）中进行2小时的体外释药，然后将其余药物溶解在磷酸盐缓冲液（pH 6.8）中。评估了水溶性（乳糖）和水不溶性（磷酸二钙）赋形剂对药物释放的影响。制成的片剂的所有物理特性均在可接受的范围内。带有瓜叶胶的片剂比带有瓜耳胶的片剂具有更大的溶胀指数。所有批次均在6小时内释放药物。片剂中基质形成剂的水平会影响药物释放。乳糖或磷酸二钙的掺入影响药物释放，但仅在较低的聚合物水平下。 karaya胶和瓜尔豆胶的组合比单个胶具有更持久的释放。

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