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首页> 外文期刊>Indian journal of physiology and pharmacology >EFFECT OF GARLIC (ALLIUM SATIVUM) ON HEMATOLOGY AND ERYTHROCYTE ANTIOXIDANT DEFENSE SYSTEM OF ALBINO RATS EXPOSED TO HEAVY METALS (NICKEL II & CHROMIUM VI)
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EFFECT OF GARLIC (ALLIUM SATIVUM) ON HEMATOLOGY AND ERYTHROCYTE ANTIOXIDANT DEFENSE SYSTEM OF ALBINO RATS EXPOSED TO HEAVY METALS (NICKEL II & CHROMIUM VI)

机译：大蒜对重金属暴露的白化病大鼠血液学和红细胞抗氧化剂防御系统的影响（尼古拉二世和六价铬）

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摘要

Heavy metals are stable environmental contaminants, causing various alterations in target tissues. Garlic has some beneficial effect in preventing heavy metal induced various alteration. The objective was to investigate the possible protective role of fresh aqueous homogenate of garlic on hematology, erythrocyte antioxidant defense system in male albino rats treated with NiSO4 and K2Cr207. Rats were divided into six groups. Group I was untreated control. Group II was given aqueous homogenate of garlic (orally). Group III was administered with nickel sulfate (i.p). Group IV was given NiSO4 and garlic simultaneously. Group V was administered with K2Cr207 (i.p). Group VI were treated simultaneously with K2Cr207 and garlic. RBC, WBC, platelet count, PCV%, hemoglobin concentration decreased significantly and clotting time increased significantly after nickel treatment. After chromium treatment all the values decreased except clotting time. Increased malondialdehyde and glutathione level after nickel and chromium treatment was observed. Also erythrocyte superoxide dismutase, glutathione peroxidase and catalase activities significantly increased after nickel and chromium treatment. Simultaneous garlic supplementation exhibited protective role to combat nickel toxicity, whereas no such beneficial effects were observed for chromium (VI). Garlic may partially prevent nickel and chromium induced alteration but such ameliorated effects as an antioxidant is only restricted on nickel induced alteration.
机译：重金属是稳定的环境污染物，可导致靶组织发生各种变化。大蒜在防止重金属引起的各种变化方面具有一定的有益作用。目的是研究新鲜的大蒜匀浆水溶液对用NiSO4和K2Cr207处理的雄性白化病大鼠血液学，红细胞抗氧化防御系统的保护作用。将大鼠分为六组。第一组未经治疗。第二组给予大蒜水匀浆（口服）。第三组施用硫酸镍（i.p）。第四组同时给予NiSO4和大蒜。将V 2组与K 2 Cr 2 O 7（i.p）一起施用。第六组同时用K2Cr207和大蒜处理。镍处理后，RBC，WBC，血小板计数，PCV％，血红蛋白浓度显着降低，凝血时间显着增加。铬处理后，除凝结时间外所有值均降低。镍和铬处理后，丙二醛和谷胱甘肽水平增加。镍和铬处理后，红细胞超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性也显着增加。同时大蒜补充剂表现出对抗镍毒性的保护作用，而铬（VI）没有观察到这种有益作用。大蒜可以部分阻止镍和铬引起的变化，但抗氧化剂等改善作用仅限于镍引起的变化。

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