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首页> 外文期刊>Indian journal of physiology and pharmacology >IN VITRO STUDY OF ACETYLCHOLINE AND HISTAMINE INDUCED CONTRACTIONS IN COLON AND RECTUM OF ADULT AND NEONATE RATS
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IN VITRO STUDY OF ACETYLCHOLINE AND HISTAMINE INDUCED CONTRACTIONS IN COLON AND RECTUM OF ADULT AND NEONATE RATS

机译：乙酰胆碱和组氨酸诱导大白鼠和大白鼠结肠和直肠内收缩的体外研究

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摘要

Contractile mechanisms of different parts of the gut in adult and neonate may not be identical due to developmental processes. The present study was undertaken to investigate acetylcholine (ACh) and histamine induced contractile responses of colon and rectum in adult and neonatal albino rats. Contractile responses were recorded from isolated in vitro preparations. The dose-response curve for ACh (0.001-100 uM) revealed dose dependent increase in contractile responses. A significantly (P<0.05) greater contractile responses (g/g wet tissue) was observed in rectum as compared to colon. Atropine pretreatment significantly blocked ACh responses in both rectum and colon. The blockade was higher in adult preparations. The dose-response study for histamine (0.001-100 uM) did not show any significant difference between rectum and colon. Histamine (100 uM) induced contractions were significantly (P<0.05) increased after pretreatment with pheniramine (100 uM) in adult rectum. This potentiating response of pheniramine was absent in neonate rectum. Such effect was also not seen in colon of both adult and neonate. The present investigation indicates that the contractile responses induced by ACh are similar in both adult and neonate, excepting that the blocking effect of atropine in colon was more pronounced in adult as compared to neonate. Further, the results also indicated different mechanism of histamine action in adults and neonates as evidenced by the significant enhancement of contractions by pheniramine only in adult rectum. Therefore, the present results indicate the existence of a different cholinergic and histaminergic activity in adult and neonate as well as in rectal and colonic tissue.
机译：由于发育过程，成年和新生儿肠道不同部位的收缩机制可能不同。本研究旨在研究乙酰胆碱（ACh）和组胺引起的成年和新生白化病大鼠结肠和直肠的收缩反应。从分离的体外制剂中记录收缩反应。 ACh（0.001-100 uM）的剂量反应曲线显示了收缩反应的剂量依赖性增加。与结肠相比，直肠中的收缩反应（g / g湿组织）明显更大（P <0.05）。阿托品预处理可显着阻断直肠和结肠的ACh反应。成人制剂中的封锁较高。组胺（0.001-100 uM）的剂量反应研究未显示直肠和结肠之间有任何显着差异。组胺（100 uM）预处理的成人直肠中，组胺（100 uM）引起的收缩显着增加（P <0.05）。新生儿直肠中不存在苯乙胺的这种增强反应。在成人和新生儿的结肠中也未观察到这种作用。本研究表明，ACh诱导的收缩反应在成人和新生儿中相似，除了阿托品在结肠中的阻断作用在成人中比新生儿更明显。此外，结果还表明，成人和新生儿中组胺作用的机制不同，仅在成人直肠中苯乙胺会明显增强收缩，这证明了这一点。因此，目前的结果表明在成人和新生儿以及直肠和结肠组织中存在不同的胆碱能和组胺能活性。

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