Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms.

de Mello CF; Begnini J; Jimenez Bernal RE; Rubin MA; de Bastiani J; da Costa E Jr; Wajner M

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Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms.

机译：纹状体内甲基丙二酸的给药通过谷氨酸能机制诱导旋转行为和惊厥。

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The effect of intrastriatal administration of methylmalonic acid (MMA), a metabolite that accumulates in methylmalonic aciduria, on behavior of adult male Wistar rats was investigated. After cannula placing, rats received unilateral intrastriatal injections of MMA (buffered to pH 7.4 with NaOH) or NaCl. MMA induced rotational behavior toward the contralateral side of injection and clonic convulsions in a dose-dependent manner. Rotational behavior and convulsions were prevented by intrastriatal preadministration of MK-801 and attenuated by preadministration of succinate. This study provides evidence for a participation of NMDA receptors in the MMA-induced behavioral alterations, where succinate dehydrogenase inhibition seems to have a pivotal role.

机译：研究了纹状体内给予甲基丙二酸尿中的代谢产物甲基丙二酸（MMA）对成年雄性Wistar大鼠行为的影响。放置套管后，大鼠接受单侧纹状体内注射MMA（用NaOH缓冲至pH 7.4）或NaCl。 MMA以剂量依赖的方式向注射和阵挛性抽搐的对侧旋转。纹状体内预先给予MK-801可防止旋转行为和惊厥，琥珀酸预先给予可减轻旋转行为和惊厥。这项研究提供了NMDA受体参与MMA诱导的行为改变的证据，其中琥珀酸脱氢酶抑制作用似乎起着关键作用。

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《Brain research》 |1996年第2期|共6页
作者
de Mello CF; Begnini J; Jimenez Bernal RE; Rubin MA; de Bastiani J; da Costa E Jr; Wajner M;
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正文语种 eng
中图分类基础医学;
关键词
Glutamic Acid; Methylmalonic Acid; Neostriatum; Seizures; Stereotyped Behavior; 谷氨酸; 甲基丙二酸; 新纹状体; 发作; 刻板行为;

机译：Glutamic Acid;Methylmalonic Acid;Neostriatum;Seizures;Stereotyped Behavior;谷氨酸;甲基丙二酸;新纹状体;发作;刻板行为;

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1. Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms. [J] . de Mello CF, Begnini J, Jimenez Bernal RE, Brain research . 1996,第1a2期

机译：纹状体内甲基丙二酸的给药通过谷氨酸能机制诱导旋转行为和惊厥。
2. Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+,K+-ATPase activity in the rat striatum and cerebral cortex. [J] . Malfatti CR, Royes LF, Francescato L, Epilepsia: Journal of the International League against Epilepsy . 2003,第6期

机译：纹状体内注射甲基丙二酸会引起惊厥和TBARS产生，并改变大鼠纹状体和大脑皮层中的Na +，K + -ATPase活性。
3. Intrastriatal administration of 3-hydroxyglutaric acid induces convulsions and striatal lesions in rats. [J] . de-Mello CF, Kolker S, Ahlemeyer B, Brain research . 2001,第1a2期

机译：纹状体内注射3-羟基戊二酸可诱发大鼠惊厥和纹状体病变。
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7. Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+,K+-ATPase activity in the rat striatum and cerebral cortex [O] . Malfatti, CRM, Royes, LFF, Francescato, L., 2003

机译：纹状体内甲基丙二酸的给药会引起惊厥和TBARS产生，并改变大鼠纹状体和大脑皮层中的Na +，K + -ATPase活性

Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms.

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