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首页> 外文期刊>Indian journal of physiology and pharmacology >ASSESSMENT OF MYOCARDIAL MECHANICS IN OVERWEIGHT AND OBESE INDIAN SUBJECTS
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ASSESSMENT OF MYOCARDIAL MECHANICS IN OVERWEIGHT AND OBESE INDIAN SUBJECTS

机译：超重和肥胖印度受试者的心肌力学评估

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摘要

Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. The study was designed to determine the direct effect of various grades of isolated obesity on Echocardiographic indices of systolic and diastolic left ventricular function. Forty five overweight & obese and 30 normal weight, serving personnel without any other pathological condition were studied. Group I (n=23) consisted of subjects with normal weight and body mass index (BMI 18.5-22.9 kg/m2), Group II (n=28) of overweight subjects (BMI 23-24.9 kg/m2) and Group III (n=24) of obese subjects (BMI >25 kg/m2). Echocardiographic indices of systolic and diastolic function were obtained and dysfunction was assumed when at least two values differed by >2 SD from the normal weight group. Ejection fraction was increased (p=0.001) in group II and III however fractional shortening was increased significantly in group III (<0.001). Left ventricular dimensions (EDD & ESD) were increased (P<0.001, 0.002) but relative wall thickness was unchanged in group II & III. Systolic dysfunction was not observed in any of the obese patients. The deceleration time was increased (P<0.01) in overweight and obese subjects compared to normal group individuals. No difference was found between obesity subgroups. Subclinical diastolic dysfunction in the form of reduced E/A ratio and increased deceleration time was more prevalent among obese subjects. BMI correlated significantly with indices of left ventricular systolic and diastolic function. Subclinical left ventricular diastolic dysfunction was noted in all grades of obesity which correlates with BMI.
机译：肥胖与心血管发病率和死亡率增加有关。孤立性肥胖对心脏功能的直接影响尚不明确。该研究旨在确定各种程度的孤立肥胖对超声心动图的收缩压和舒张压左心室功能的直接影响。研究了45名超重和肥胖和30正常体重的服务人员，他们没有任何其他病理状况。第一组（n = 23）包括体重和体重指数正常（BMI 18.5-22.9 kg / m2），第二组（n = 28）超重受试者（BMI 23-24.9 kg / m2）和第三组（n = 28） n = 24）的肥胖受试者（BMI> 25 kg / m2）。当至少两个值与正常体重组的差值> 2 SD时，获得了超声心动图的收缩和舒张功能指数，并认为功能障碍。 II和III组的射血分数增加（p = 0.001），而III组的射血分数缩短显着增加（<0.001）。 II和III组左心室尺寸（EDD和ESD）增加（P <0.001，0.002），但相对壁厚不变。在任何肥胖患者中均未观察到收缩功能障碍。与正常组相比，超重和肥胖受试者的减速时间增加（P <0.01）。肥胖亚组之间没有发现差异。以E / A比率降低和减速时间增加为形式的亚临床舒张功能障碍在肥胖受试者中更为普遍。 BMI与左心室收缩和舒张功能指数显着相关。在与BMI相关的所有等级的肥胖中都注意到亚临床的左心室舒张功能障碍。

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