...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Indian journal of physiology and pharmacology >Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion.
【24h】

Antidiabetic and antiulcer effects of extract of Eugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion.

机译：番木瓜种子提取物对轻度糖尿病大鼠的抗糖尿病和抗溃疡作用：胃粘膜进攻性胃酸胃蛋白酶分泌的研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diabetes has been reported to increase propensity to peptic ulceration through its effect both on offensive and defensive mucosal factors. Seeds of Eugenia jambolana (EJ) have been reported to have both antidiabetic as well as ulcer protective effects. The present study evaluates the antidiabetic effects of ethanolic extract of dried seed kernel of Eugenia jambolana (EJE) and its comparative effect on gastric ulceration and acid-pepsin secretion with standard antisecretory FL-blocker. Ranitidine and antidiabetic glibenclamide with a premise that Eugenia jambolana may show better ulcer healing effects by promoting defensive or reducing offensive mucosal factors in mild diabetes (MD) rats. MD was produced in adult rats by administration of streptozotocin (45 mg/kg, ip). EJE was given orally in the doses of 100-400 mg/kg for 10 days and in the dose of 200 mg/kg for 30 days respectively to study its dose- and time-dependent effects on various diabetic parameters like blood glucose, serum cholesterol and triglycerides, insulin level and glycosylated hemoglobin. For ulcer protective and gastric secretion studies, EJE (200 mg/kg) was given orally for 10 days against 2 h cold restraint stress (CRS)-, 4 h pylorus ligation (PL), aspirin (ASP, 200 mg/kg, 4 h)--and 95% ethanol (EtOH, 1 ml/200 g, 1 h)-induced gastric ulcers and offensive acid-pepsin secretion after 4 h PL with co-occurring MD in rats. EJE showed dose-dependent decrease in blood glucose level in MD rats. Blood glucose level remained stable in mild diabetic rats from 3rd day onwards after streptozotocin administration (taken as 1st day for treatment) and EJE (200 mg/kg) showed anti-hyperglycemic effect on 10th day of its administration. Further, EJE in the above dose also decreased cholesterol level with little or no effect on triglycerides level and reversed the decrease and increase in insulin and glycosylated hemoglobin level near to the normal level as observed alter 30 days treatment in MD rats. MD rats exhibited an increased propensity to gastric ulceration induced by CRS, ASP, EtOH and PL and caused increase in acid-pepsin secretion. EJE was not only effective in reversing the increased propensity to ulceration in diabetic rats but also decreased the acid-pepsin output better than glibenclamide. The ulcer protective effect of Eugenia jambolana seems to be due to its antidiabetic and gastric antisecretory effects.
机译：据报道，糖尿病通过其对进攻性和防御性粘膜因子的作用而增加了消化性溃疡的倾向。据报道，Eugenia jambolana（EJ）种子具有抗糖尿病和溃疡保护作用。本研究评估了标准的分泌型FL受体阻滞剂Eugenia jambolana（EJE）干燥种子仁乙醇提取物的抗糖尿病作用及其对胃溃疡和酸性胃蛋白酶分泌的比较作用。雷尼替丁和抗糖尿病药格列本脲的前提是，番石榴可以通过促进轻度糖尿病（MD）大鼠的防御性或减少攻击性粘膜因子而显示出更好的溃疡愈合效果。通过链脲佐菌素（45 mg / kg，腹腔注射）在成年大鼠中产生MD。分别以100-400 mg / kg的剂量口服EJE 10天和以200 mg / kg的剂量口服30天，以研究其对各种糖尿病参数（如血糖，血清胆固醇）的剂量依赖性和时间依赖性甘油三酸酯，胰岛素水平和糖基化血红蛋白。对于溃疡保护和胃分泌物研究，口服口服EJE（200 mg / kg）10天，抵抗2小时的冷约束压力（CRS）-，幽门结扎（PL）4小时，阿司匹林（ASP，200 mg / kg，4 h）-大鼠在并发MD的同时发生4 h后，由95％乙醇（EtOH，1 ml / 200 g，1 h）诱导的胃溃疡和令人讨厌的胃酸胃蛋白酶分泌。 EJE在MD大鼠中显示出剂量依赖性的血糖水平降低。链脲佐菌素给药后第3天（治疗第1天）开始，轻度糖尿病大鼠的血糖水平保持稳定，EJE（200 mg / kg）在给药第10天显示出降血糖作用。此外，如在MD大鼠中治疗30天后观察到的，上述剂量的EJE还降低了胆固醇水平，而对甘油三酸酯水平几乎没有或没有影响，并且逆转了胰岛素和糖基化血红蛋白水平的降低和增加，接近正常水平。 MD大鼠表现出由CRS，ASP，EtOH和PL引起的胃溃疡倾向增加，并引起酸性胃蛋白酶分泌增加。 EJE不仅可以有效逆转糖尿病大鼠的溃疡倾向，而且可以比glibenclamide更好地降低胃酸分泌。番木瓜的溃疡保护作用似乎归因于其抗糖尿病和胃的抗分泌作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号