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首页> 外文期刊>Brain research >Measurement of presynaptic zinc changes in hippocampal mossy fibers.
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Measurement of presynaptic zinc changes in hippocampal mossy fibers.

机译：测量海马苔藓纤维中突触前锌的变化。

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摘要

The hippocampal mossy fiber terminals of CA3 area contain high levels of vesicular zinc that is released in a calcium-dependent way, following high-frequency stimulation. However the properties of zinc release during normal synaptic transmission, paired-pulse facilitation and mossy fiber long-term potentiation are still unknown. Using the fluorescent zinc probe N-(6-methoxy-8-quinolyl)-para-toluenesulfonamide, we measured fast mossy fiber zinc changes indicating that zinc is released following single and low levels of electrical stimulation. The observed presynaptic zinc signals are maintained during the expression of mossy fiber long-term potentiation, assumed to be mediated by an increase in transmitter release, and are enhanced during paired-pulse facilitation. This zinc enhancement is, like paired-pulse facilitation, reduced during established long-term potentiation. The correlation between the paired-pulse evoked zinc and field potential responses supports the idea that zinc is co-released with glutamate.
机译：CA3区的海马长满苔藓的纤维末端含有高水平的囊泡锌，在高频刺激后以钙依赖性方式释放。然而，在正常的突触传递，成对脉冲促进和苔藓纤维长期增强过程中锌释放的特性仍然未知。使用荧光锌探针N-（6-甲氧基-8-喹啉基）-对甲苯磺酰胺，我们测量了苔藓纤维中锌的快速变化，表明锌在单次和低水平电刺激后都会释放。观察到的突触前锌信号在长满苔藓纤维的长期增强表达期间得以维持，假定是由递质释放的增加介导的，而在成对脉冲促进过程中则得到增强。像成对脉冲促进一样，这种锌增强在建立的长期增强过程中也会降低。成对脉冲诱发的锌与场电势响应之间的相关性支持锌与谷氨酸共释放的观点。

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