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Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats.

机译:摄入蔗糖会引起快感大鼠伏伏核的Fos表达降低。

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摘要

Chronic mild stress (CMS), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) activation associated with a rewarding stimulus. Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose. Fewer Fos-positive neurons were observed in the NAc in CMS versus control rats. These findings have implications for the mechanisms underlying reduced responding to pleasurable stimuli associated with depression.
机译:慢性轻度应激(CMS)是与快感缺乏症相关的抑郁症动物模型,用于检查与奖励刺激相关的伏伏核(NAc)激活。在大鼠中进行CMS 4周后,摄入固定体积的蔗糖后测量NAc Fos免疫反应性。与对照组相比,在CMS的NAc中观察到更少的Fos阳性神经元。这些发现对降低与抑郁症相关的愉悦刺激的反应机制具有潜在意义。

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