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首页> 外文期刊>Brain research >Arcuate nucleus inputs onto subfornical organ neurons that respond to plasma hypernatremia and angiotensin II.
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Arcuate nucleus inputs onto subfornical organ neurons that respond to plasma hypernatremia and angiotensin II.

机译：弓形核输入到对血浆高钠血症和血管紧张素II有反应的respond下器官神经元。

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Experiments were done in urethane anesthetized rats to investigate the effect of electrical and glutamate stimulation of arcuate nucleus (Arc) on the discharge rate of subfornical organ (SFO) neurons that responded to either plasma hypernatremia or angiotensin II (ANG II). Extracellular recordings were made from 253 histologically verified single neurons in SFO. Of these, 40.3% (102/253) responded with excitation and 10% (25/253) with inhibition to Arc stimulation. Thirty-five (34.3%) of the units excited by Arc were also excited by intracarotid infusion of hypertonic (0.5 M) NaCl. In addition, 37 (36.3%) of the units excited by Arc were also excited by intracarotid infusion of ANG II. Furthermore, 10 (40.0%) of the units inhibited by Arc were found to be excited by ANG II. None of the units inhibited by Arc stimulation were responsive to plasma hypernatremia. These data indicate that inputs from Arc neurons converge onto SFO neurons that alter their discharge rate during changes in plasma concentration of Na+ or ANG II. These results suggest that Arc may be involved in body fluid balance and circulatory regulation by modulating the activity of SFO neurons that function in the detection of blood-borne signals from the depletion of intra- and extra-cellular fluid volumes.
机译：在氨基甲酸乙酯麻醉的大鼠中进行了实验，以研究弓形核（Arc）的电刺激和谷氨酸刺激对对血浆高钠血症或血管紧张素II（ANG II）有反应的for下器官（SFO）神经元放电速率的影响。从SFO中的253个经过组织学验证的单个神经元进行细胞外记录。其中，有40.3％（102/253）的人对兴奋有反应，有10％（25/253）的人对电弧刺激有抑制作用。颈动脉内输注高渗（0.5 M）NaCl也会激发三十五（34.3％）个被Arc激发的单位。此外，通过颈动脉内注入ANG II也激发了37个（36.3％）被Arc激发的单元。此外，发现ANG（II）激发了10个（40.0％）被Arc抑制的单元。弧光刺激抑制的任何单位均不响应血浆高钠血症。这些数据表明，来自弧神经元的输入会汇聚到SFO神经元上，从而在Na +或ANG II血浆浓度变化期间改变其放电速率。这些结果表明，Arc可能通过调节SFO神经元的活性来参与体液平衡和循环调节，该SFO神经元的功能是通过检测细胞内和细胞外液量的消耗来检测血源信号。

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