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首页> 外文期刊>Brain research >Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's Disease: linkage of poorer cognitive performance to tau pathology in forebrain.
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Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's Disease: linkage of poorer cognitive performance to tau pathology in forebrain.

机译：APPsw和P301L模型用于阿尔茨海默氏病的多指标行为比较：较差的认知表现与前脑tau病理的联系。

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摘要

APPsw transgenic mice bearing the "Swedish" amyloid precursor protein (APP) mutation and JNPL3 transgenic mice bearing the P301L (Tau) mutation were compared to control non-transgenic (NT) mice in an extensive behavioral test battery administered between 5 and 8.5 months of age. APP mice were impaired in a variety of cognitive-based tasks prior to overt Abeta plaque development, making involvement of mutant APP overexpression and/or oligomeric Abeta assemblies most likely. Although Tau mice, as a group, were not impaired in any single behavioral measure, a collective assessment of behavioral measures through discriminant function analysis showed that Tau mice were impaired in overall behavioral (cognitive) performance. Moreover, correlation analyses involving Tau mice alone revealed linkage between poorer cognitive performance in all three water maze tasks and the number of neurofibrillary tangle (NFT)-containing neurons in neocortex and hippocampus. These findings indicate that: (1) APP mice show early and extensive cognitive impairment before evident Abeta deposition, and (2) the process or product of NFT formation in Tau mice is sufficient to deleteriously impact cognitive performance.
机译：在5至8.5个月的行为试验期间，将携带“瑞典”淀粉样前体蛋白（APP）突变的APPsw转基因小鼠和携带P301L（Tau）突变的JNPL3转基因小鼠与对照非转基因（NT）小鼠进行了比较。年龄。在明显的Abeta斑块形成之前，APP小鼠在各种基于认知的任务中受损，这使得突变APP过度表达和/或寡聚Abeta装配极有可能参与其中。尽管Tau小鼠作为一个整体，在任何一项行为指标上均未受到损害，但是通过判别功能分析对行为指标进行的集体评估显示，Tau小鼠的整体行为（认知）表现受到了损害。此外，仅涉及Tau小鼠的相关分析表明，在所有三个水迷宫任务中较差的认知表现与新皮质和海马中含神经原纤维缠结（NFT）的神经元数量之间存在关联。这些发现表明：（1）APP小鼠在明显的Abeta沉积之前显示出早期和广泛的认知障碍，并且（2）Tau小鼠中NFT形成的过程或产物足以有害地影响认知能力。

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