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首页> 外文期刊>Brain research >Nicotine-mediated plasticity in robust nucleus of the archistriatum of the adult zebra finch.
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Nicotine-mediated plasticity in robust nucleus of the archistriatum of the adult zebra finch.

机译：尼古丁介导的成年斑马雀雀原核坚固核中的可塑性。

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Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a valuable model to study synaptic plasticity and its implications to behavioral learning. Electrophysiological recordings in the robust nucleus of the archistriatum (RA) in adult zebra finch brain slices reveal that tetanic stimulation alone does not produce LTP. However, LTP is induced by such stimulation in the presence of nicotine. The nicotine-mediated LTP is blocked by dihydro-beta-erythroidine (DHbetaE, 1 microM), an antagonist having a greater effect against nAChRs containing the alpha 4 subunit. In the presence of methyllcaconitine (MLA, 10 nM), an antagonist of nAChRs containing the alpha 7 subunit, a long-term depression (LTD) is unmasked, implicating a bi-directional type of plasticity in the zebra finch RA, which is modulated by differential activation of nAChR subtypes. Intracellular recordings from single neurons show a depression of the afterhyperpolarization (AHP) and an increase in frequency of evoked and spontaneous action potentials in the presence of nicotine. These results suggest that nicotinic cholinergic mechanisms may play a critical role in synaptic plasticity in the zebra finch song system and thereby influence song learning and plasticity.
机译：神经元烟碱型乙酰胆碱受体（nAChRs）的激活调节长期增强（LTP）的诱导，这是一种可能的学习细胞机制。进行这项研究来确定尼古丁对nAChRs的激活对鸣禽斑马雀的长期可塑性的影响，这是研究突触可塑性及其对行为学习的影响的有价值的模型。在成年斑马雀科大脑切片的原核生物健壮核中的电生理记录显示，仅强直刺激不会产生LTP。然而，在尼古丁的存在下，LTP是由这种刺激诱导的。尼古丁介导的LTP被二氢-β-类胡萝卜素（DHbetaE，1 microM）阻断，该拮抗剂对含有α4亚基的nAChR具有更大的作用。在含有α7亚基的nAChRs拮抗剂甲基lcaconitine（MLA，10 nM）的存在下，长期的抑郁症（LTD）未被掩盖，这表明斑马雀科RA中存在双向可塑性通过nAChR亚型的差异激活。来自单个神经元的细胞内记录显示，在存在尼古丁的情况下，超极化后（AHP）降低，诱发和自发动作电位的频率增加。这些结果表明，烟碱胆碱能机制可能在斑马雀科歌曲系统中的突触可塑性中起关键作用，从而影响歌曲的学习和可塑性。

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