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首页> 外文期刊>Brain research >Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric erosions in rats.
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Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric erosions in rats.

机译：脑室内CRF抑制冷约束诱导的迷走神经背运动核中的c-fos表达和胃糜烂。

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摘要

Acute exposure to cold-restraint induces vagal-dependent gastric erosions associated with activation of neurons in the dorsal motor nucleus of the vagus (DMN) in rats. The influence of intracerebroventricular (i.c.v.) injection of corticotropin-releasing factor (CRF) (10 micrograms) on c-fos expression in the brain and gastric erosions induced by 3 h cold-restraint was investigated in conscious rats. In cold-restraint exposed rats, CRF injected i.c.v. inhibited gastric erosions and the number of Fos positive neurons in the DMN by 93 and 72%, respectively, while Fos labelling in the nucleus tractus solitarius (NTS) was increased by 5-fold compared with vehicle group. c-fos expression was also induced in the central amygdala by i.c.v. CRF, unlike the vehicle-injected group exposed to cold-restraint. c-fos expression induced by cold-restraint in the raphe pallidus (Rpa) and paraventricular nucleus of the hypothalamus was not altered by i.c.v. CRF. These data indicate that central CRF-induced gastric protection results from the inhibition of DMN neuronal activity enhanced by cold-restraint. CRF action on DMN neurons may be related to the increase in the NTS and central amygdala inputs leading to inhibition of DMN neurons rather than to the decrease in the excitatory input from the caudal raphe projections to the DMN.
机译：急性暴露于冷约束下会诱发迷走神经依赖性胃糜烂，与大鼠迷走神经背运动核（DMN）中神经元的激活有关。在清醒大鼠中研究了脑室内（i.c.v.）注射促肾上腺皮质激素释放因子（CRF）（10微克）对c和fos表达的影响，其中c-fos在3 h冷约束诱导的脑部和胃部糜烂中起作用。在暴露于冷约束的大鼠中，CRF静脉内注射。与媒介物组相比，DMN中抑制胃糜烂和DMN中Fos阳性神经元的数量分别增加了93％和72％，而孤束核（NTS）中的Fos标记增加了5倍。 i.c.v.在中央杏仁核中也诱导了c-fos表达。 CRF与接受冷约束的车辆注射组不同。 i.c.v.并没有改变冷约束下睑裂（Rpa）和下丘脑室旁核诱导的c-fos表达。 CRF。这些数据表明中枢CRF诱导的胃保护作用是由于冷约束增强了对DMN神经元活性的抑制。 CRF对DMN神经元的作用可能与NTS和中央杏仁核输入的增加导致DMN神经元的抑制有关，而不是与从尾缝投射到DMN的兴奋性输入减少有关。

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