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首页> 外文期刊>Brain research >Effect of intermittent hypoxia on long-term potentiation in rat hippocampal slices.
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Effect of intermittent hypoxia on long-term potentiation in rat hippocampal slices.

机译：间歇性缺氧对大鼠海马切片长期增强的影响。

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Intermittent hypoxia (IH) during sleep has been shown to induce apoptosis in a time-dependent manner and spatial learning deficits in adult rats. Recently, we have demonstrated that IH induced significant decreases in Ser-133-phosphorylated cAMP-response element-binding protein (pCREB) without changes in total CREB. The expression of cleaved caspase 3 in the hippocampal CA1, a marker of apoptosis, peaked at 3 days of IH and returned to normoxic values at 14 days of IH. In addition, biphasic changes in spatial task learning were correlated with the CREB phosphorylation time course. In the present study, the rat hippocampal slice preparation was used to evaluate the ability to induce and maintain a CA1 population spike long-term potentiation (PS-LTP) in room air (RA)-maintained and IH-exposed rats. A significant decrease in the ability to sustain PS-LTP for 15 min in slices prepared from IH-exposed rats for either 3 days (34% of total) or 7 days (51% of total) as compared to slices prepared from RA-maintained rats (76% of total) was observed. These results suggest that the diminishment in the ability of neuronal tissue to express and sustain PS-LTP is correlated with previously reported biphasic changes in CREB phosphorylation and programmed cell death.
机译：睡眠中的间歇性缺氧（IH）已显示成时间依赖性地诱导凋亡，并在成年大鼠中引起空间学习障碍。最近，我们已经证明IH诱导Ser-133磷酸化的cAMP反应元件结合蛋白（pCREB）明显减少，而总CREB却没有改变。海马CA1中切割的半胱天冬酶3的表达是细胞凋亡的标志物，在IH第3天达到高峰，在IH第14天恢复到常氧值。此外，空间任务学习中的双相变化与CREB磷酸化时间进程相关。在本研究中，大鼠海马切片制剂用于评估诱导和维持在室内空气（RA）和IH暴露的大鼠中CA1群体峰值长期增强（PS-LTP）的能力。与由RA维持的切片相比，由暴露于IH的大鼠制备的切片连续3天（占总数的34％）或7天（占总数的51％）使PS-LTP维持15分钟的能力显着降低观察到大鼠（占总数的76％）。这些结果表明，神经元组织表达和维持PS-LTP的能力下降与先前报道的CREB磷酸化和程序性细胞死亡的双相变化有关。

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