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首页> 外文期刊>Brain research >Distribution and ultrastructure of dopaminergic neurons in the dorsal motor nucleus of the vagus projecting to the stomach of the rat.
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Distribution and ultrastructure of dopaminergic neurons in the dorsal motor nucleus of the vagus projecting to the stomach of the rat.

机译：多巴胺能神经元在迷走神经背运动核中的分布和超微结构，该迷走神经突向大鼠的胃。

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摘要

Almost all parasympathetic preganglionic motor neurons contain acetylcholine, whereas quite a few motor neurons in the dorsal motor nucleus of the vagus (DMV) contain dopamine. We determined the distribution and ultrastructure of these dopaminergic neurons with double-labeling immunohistochemistry for tyrosine hydroxylase (TH) and the retrograde tracer cholera toxin subunit b (CTb) following its injection into the stomach. A few TH-immunoreactive (TH-ir) neurons were found in the rostral half of the DMV, while a moderate number of these neurons were found in the caudal half. Most of the TH-ir neurons (78.4%) were double-labeled for CTb in the half of the DMV caudal to the area postrema, but only a few TH-ir neurons (5.5%) were double-labeled in the rostral half. About 20% of gastric motor neurons showed TH-immunoreactivity in the caudal half of the DMV, but only 0.3% were TH-ir in the rostral half. In all gastric motor neurons, 8.1% were double-labeled for TH. The ultrastructure of the TH-ir neurons inthe caudal DMV was determined with immuno-gold-silver labeling. The TH-ir neurons were small (20.4x12.4 microm), round or oval, and contained numerous mitochondria, many free ribosomes, several Golgi apparatuses, a round nucleus and a few Nissl bodies. The average number of axosomatic terminals per section was 4.0. More than half of them contained round synaptic vesicles and made asymmetric synaptic contacts (Gray's type I). Most of the axodendritic terminals contacting TH-ir dendrites were Gray's type I (90%), but a few contained pleomorphic vesicles and made symmetric synaptic contacts (Gray's type II).
机译：几乎所有副交感神经节前运动神经元均含有乙酰胆碱，而迷走神经背运动核（DMV）中的相当多运动神经元均含有多巴胺。我们通过酪氨酸羟化酶（TH）和逆行示踪示踪霍乱毒素亚基b（CTb）的双标记免疫组织化学注射到胃中后，确定了这些多巴胺能神经元的分布和超微结构。在DMV的前半部发现了一些TH免疫反应（TH-ir）神经元，而在尾半部发现了中等数量的这些神经元。大部分TH-ir神经元（78.4％）在尾部至后区DMV的一半处被CTb双重标记，但只有少数TH-ir神经元（5.5％）在鼻端部被双重标记。大约20％的胃运动神经元在DMV的尾半部分显示TH-免疫反应性，但是在头端的半数中只有0.3％是TH-ir。在所有胃运动神经元中，有8.1％的人为TH双重标记。尾部DMV中TH-ir神经元的超微结构用免疫金银标记确定。 TH-ir神经元较小（20.4x12.4微米），圆形或椭圆形，包含许多线粒体，许多游离核糖体，数个高尔基体，一个圆核和几个尼氏小体。每节的平均无躯体末端数量为4.0。它们中的一半以上包含圆形突触小泡并形成不对称的突触接触（格雷的I型）。接触TH-ir树突的大多数轴突末梢是Gray的I型（90％），但少数包含多形囊泡并形成对称的突触接触（Gray的II型）。

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