Role of Initial Higher Dose of Paracetamol versus Conventional Usual Dose, in the Management of Pyrexia in Pediatrics age group of Patients-A Clinical Study

Sharbeshwar Kumar

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Role of Initial Higher Dose of Paracetamol versus Conventional Usual Dose, in the Management of Pyrexia in Pediatrics age group of Patients-A Clinical Study

机译：初始对乙酰氨基酚高剂量与常规剂量相比在小儿年龄段患者发热性发热中的作用-临床研究

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Fever is an elevation of body temperature above the normal range as the result of change in thermoregulatory centre in the anterior hypothalamus. In the present study, it is observed that initially a higher dose of paracetamol improve the rate of temperature decrease obtaining effective drug, concentration, as also suggested by Wilson et al. Initial higher dose of paracetamol is not only responsible for improvement of symptoms of discomfort, restlessness and irritability but it also prevent complications of Pyrexia. Mahar et al recommended cold therapy initially to decrease temperature but some-times it may cause shivering and is associated with crying and symptoms of discomfort in children. Fever is a very common symptom in children. Febrile children often are irritable and restless and may experience diffuse, nonspecific pain. Parents are usually very much concern about these symptoms in children. Most Physicians, therefore tries to lower the temperature without delay, because antipyretic agents improve the symptoms of discomfort. Among the available antipyretic agents, Paracetamol is one of most widely used because it has an antipyretic efficacy equivalent to the other antipyretic drugs with a good safety profile. Its efficacy is dose dependent. The recommended conventional dose is 15mg/Kg of body weight every 6 hours.

机译：发烧是由于下丘脑前部温度调节中心发生变化而导致体温升高到正常范围以上。在本研究中，观察到，最初，较高剂量的扑热息痛可提高温度降低的速率，从而获得有效的药物浓度，这也由Wilson等人提出。最初较高剂量的扑热息痛不仅负责改善不适，不安和烦躁的症状，而且还可以预防发热。 Mahar等人建议最初使用冷疗法降低温度，但有时可能会引起发抖，并伴有哭闹和儿童不适症状。发烧是儿童的一种非常常见的症状。高热的孩子常常烦躁不安，可能会经历弥漫性的非特异性疼痛。父母通常非常关心儿童的这些症状。因此，大多数医生试图立即降低温度，因为退热药可改善不适症状。在可用的解热剂中，扑热息痛是使用最广泛的一种，因为它的解热功效与其他具有良好安全性的解热药相当。其功效是剂量依赖性的。建议的常规剂量是每6小时15mg / Kg体重。

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《Indian medical journal》 |2012年第5期|共2页
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Sharbeshwar Kumar;
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1. Role of Initial Higher Dose of Paracetamol versus Conventional Usual Dose, in the Management of Pyrexia in Pediatrics age group of Patients-A Clinical Study [J] . Sharbeshwar Kumar Indian medical journal . 2012,第5期

机译：初始对乙酰氨基酚高剂量与常规剂量相比在小儿年龄段患者发热性发热中的作用-临床研究
2. Challenging the One-Dose-Fits-All Model for Insulin in the Acute Treatment of Pediatric Diabetic Ketoacidosis. A Critical Appraisal of "Low-Dose Versus Standard-Dose Insulin in Pediatric Diabetic Ketoacidosis: A Randomized Clinical Trial" by Nallasamy et al (JAMA Pediatrics 2014; 168:999-1005) [J] . Orwoll Benjamin Edward Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies . 2016,第10期

机译：在小儿糖尿病酮症酸中毒的急性治疗中挑战胰岛素的一剂全配模型。 Nallasamy等人（“ JAMA Pediatrics 2014; 168：999-1005”）对“小儿糖尿病性酮症酸中毒的低剂量与标准剂量胰岛素的随机临床试验”进行了严格的评估。
3. Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children. [J] . Kokki H, Kokki M Clinical drug investigation . 2010,第6期

机译：酮洛芬与扑热息痛（对乙酰氨基酚）或布洛芬治疗发烧：两项儿童随机，双盲，双模拟，平行组，重复剂量，多中心，III期研究的结果。
4. A Comparative Study Using Numerical Methods for Surface X Ray Doses with Conventional and Digital Radiology Equipment in Pediatric Radiology [C] . Posa Ioan Dan, Georgescu Remus Florin, Ciobanu Virgil, International Conference of Numerical Analysis and Applied Mathematics . 2011

机译：使用常规和数字放射设备在儿科放射学中X射线剂量的数值方法的比较研究
5. Computer simulations to estimate organ doses from clinically validated cardiac, neuro, and pediatric protocols for multiple detector computed tomography scanners. [D] . Ghita, Monica. 2009

机译：计算机模拟可从临床验证的心脏，神经和儿科方案中估算出器官剂量，以用于多个检测器计算机断层扫描仪。
6. The Efficacy and Safety of Low Dose versus Usual Dose of Hyoscine During Endoscopic Retrograde Cholangiopancreatography: A Randomized Clinical Trial [O] . Hassan Salmanroghani, Massoud Mirvakili, Mahtabalsadat Mirjalili, -1

机译：低剂量与常用剂量在内窥镜逆行胆管胆痴呆症的疗效和安全性：随机临床试验
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Role of Initial Higher Dose of Paracetamol versus Conventional Usual Dose, in the Management of Pyrexia in Pediatrics age group of Patients-A Clinical Study

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