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首页> 外文期刊>Brain research >Elevated neurofilament levels in neurological diseases.
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Elevated neurofilament levels in neurological diseases.

机译:神经系统疾病中神经丝水平升高。

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Neurofilaments, a major cytoskeletal constituent of neuronal cells, can be released into the cerebrospinal fluid during several neurodegenerative diseases. By means of a new sensitive ELISA capable of measuring 60 ng/l of neurofilament light, significant elevations were observed for different neurological disorders. Cerebral infarction presented levels of 19800+/-9100 ng/l, amyothropic lateral sclerosis 3600+/-1200 ng/l, 'relapsing-remitting' MS 2500+/-1500 ng/l, extrapyramidal symptoms 1100+/-300 ng/l, late onset AD 300+/-100 ng/l and vascular dementia 1400+/-800 ng/l. In patients with no signs of neurological diseases the upper normal level and cut-off values was determined to be below 100 ng/l. NF-L determinations will be a valuable complement in identifying neuronal degradation and can be used clinically for diagnostic and monitoring purposes.
机译:神经丝是神经元细胞的主要细胞骨架成分,在几种神经退行性疾病中可以释放到脑脊液中。通过能够测量60 ng / l神经丝光的新型灵敏ELISA,观察到了不同神经系统疾病的明显升高。脑梗死的水平为19800 +/- 9100 ng / l,肌无力性侧索硬化症3600 +/- 1200 ng / l,复发-缓解型MS 2500 +/- 1500 ng / l,锥体外系症状为1100 +/- 300 ng / l l,迟发性AD 300 +/- 100 ng / l和血管性痴呆1400 +/- 800 ng / l。在没有神经系统疾病迹象的患者中,正常水平上限和临界值被确定为低于100 ng / l。 NF-L测定将是鉴定神经元退化的宝贵补充,可在临床上用于诊断和监测目的。

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