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首页> 外文期刊>Brain research >Transhemispheric depolarizations persist in the intracerebral hemorrhage swine brain following corpus callosal transection.
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Transhemispheric depolarizations persist in the intracerebral hemorrhage swine brain following corpus callosal transection.

机译：hem体横切后，脑内出血猪脑中仍存在半脑半球去极化。

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摘要

Spontaneous episodes of spreading depression (SD) originating in multiple sources adjacent to a focal intracerebral hemorrhage (ICH) propagate into brain regions away from the lesion site soon after injury onset. Although these transient depolarizations have not been established in the opposite hemisphere of the swine ICH model, we have reported a diminishing of sensory responsiveness in this homotopic brain region following induction of a unilateral hemorrhage lesion. This study examined whether transient depolarizations exist in this distant brain region contralateral to the ICH site. Electrocorticographic (ECoG) recordings of brain activity were collected bilaterally from the primary somatosensory (SI) cortices of the swine brain prior to and immediately after an intracerebral injection of collagenase or saline or the insertion of the infusion pipette into the SI cortex of the right hemisphere. Transient depolarizations were present in both hemispheres of all the experimental groups. The earliest negative DC potential shifts were observed in the injured SI cortex within the first hour after collagenase injection, as compared to T = 3 h in the saline-injected group and T = 4 h in the infusion pipette only group. In contrast, transient depolarizations were first detected in the left SI cortex contralateral to the lesioned hemisphere within 2 h after collagenase infusion, by T = 4 h after saline infusion and by T = 3 h in the pipette only group. Propagating waves of negative DC potential shifts continued in both brain hemispheres, particularly in the ICH group, throughout the 11-h recording period. This novel finding of recurrent depolarizing waves in the hemisphere contralateral to the injury site prompted us to examine whether corpus callosal connections may play a role in this transhemispheric phenomenon. In a separate group of animals, the corpus callosum was transected prior to acquiring DC potential recordings and collagenase injection. The onset pattern of negative DC shifts in the callosotomized + collagenase-injected group was similar to the collagenase group with an intact corpus callosum. Initial generation of SD in the callosotomized + collagenase-injected group occurred by T = 1 h in the ICH injured right hemisphere and T = 2 h in the contralateral hemisphere. These transient depolarizations also persisted throughout 11-h recording period indicating that the corpus callosal transection did not hinder these remote propagating waves of depolarization. The presence of SD in the SI cortices of both hemispheres in all experimental groups of this study suggests that a focal mechanical or hemorrhagic injury increases the susceptibility of distant ipsilateral and contralateral brain regions to depolarizing perturbations. The mechanism for these transient depolarizations in the contralateral hemisphere apparently does not involve transhemispheric propagation along corpus callosal fibers.
机译：起源于局灶性脑出血（ICH）的多个来源的自发性抑郁症（SD）发作会在损伤发作后不久传播到远离病变部位的大脑区域。尽管尚未在猪ICH模型的相对半球中建立这些短暂的去极化作用，但我们已经报告了在诱发单侧出血病灶后该同位脑区域的感觉反应能力下降。这项研究检查了在与ICH部位对侧的这个较远的大脑区域中是否存在瞬时去极化。在脑内注射胶原酶或生理盐水或将移液吸管插入右半球的SI皮质之前和之后，从猪脑的初级体感（SI）皮质两侧收集脑活动的电皮质（ECoG）记录。 。在所有实验组的两个半球都存在瞬时去极化。在注射胶原酶后的第一小时内，在受伤的SI皮层中观察到最早的负DC电位移动，与之相比，注射盐水的组中T = 3 h，仅输液移液器组中T = 4 h。相比之下，胶原酶注入后2小时内，病变半球对侧的左侧SI皮层中首先检测到瞬时去极化，盐水注入后T = 4小时，仅移液器组中T = 3小时。在整个11小时的记录期间，两个脑半球（尤其是ICH组）中持续传播的负DC电位偏移波。在与损伤部位相对的半球中反复出现去极化波的新发现促使我们研究us体连接是否可能在这种跨半球现象中起作用。在另一组动物中，在获取DC电位记录和胶原酶注射之前，先切除call体。切开+胶原酶注射组中负DC移位的发作模式与with体完整的胶原酶组相似。注射切骨术+胶原酶的组中SD的初始生成发生在ICH受伤的右半球T = 1小时，对侧半球T = 2小时。这些短暂的去极化也持续了整个11小时的记录时间，表明call体横切并不妨碍这些遥远传播的去极化波。在这项研究的所有实验组中，两个半球的SI皮质中均存在SD，这表明机械性或出血性局灶性损伤增加了远侧同侧和对侧脑区对去极化扰动的敏感性。对侧半球中这些短暂去极化的机制显然不涉及沿体call骨纤维的跨半球传播。

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