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首页> 外文期刊>Brain research >Morphine-induced place preference: Involvement of the central amygdala NMDA receptors.
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Morphine-induced place preference: Involvement of the central amygdala NMDA receptors.

机译：吗啡诱导的位置偏爱：参与中央杏仁核NMDA受体。

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摘要

In the present study, the effects of bilateral injections of N-methyl-d-aspartate (NMDA) receptor agonist and/or antagonist into the central amygdala (CeA) on the acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Animals that received 3 daily subcutaneous (s.c.) injections of morphine (1-9 mg/kg) or saline (1.0 ml/kg) indicated a significant preference for compartment paired with morphine in a dose dependent manner. Intra-CeA administration of the NMDA (0.01, 0.1 or 1 mug/rat) with an ineffective dose of morphine (1 mg/kg, s.c.) elicited a significant CPP. Administration of the non-competitive NMDA receptor antagonist, MK-801 (0.1, 0.3 or 0.5 mug/rat), into the central amygdala dose-dependently inhibited the morphine (6 mg/kg, s.c.)-induced place preference. Furthermore, intra-CeA administration of MK-801 (0.25, 0.5 or 1 mug/rat) reduced the response induced by NMDA (1 mug/rat, intra-CeA) plus morphine (1 mg/kg, s.c.). Neither NMDA nor MK-801 alone produce a significant place preference or place aversion. Moreover, intra-CeA injection of NMDA but not MK-801 before testing significantly increased the expression of morphine (6 mg/kg, s.c.)-induced place preference. NMDA or MK-801 injections into the CeA had no effects on locomotor activity on the testing sessions. These results suggest that the NMDA receptor mechanisms in the central amygdala may be involved in the acquisition and expression of morphine-induced place preference.
机译：在本研究中，向中央杏仁核（CeA）双边注射N-甲基-d-天冬氨酸（NMDA）受体激动剂和/或拮抗剂对吗啡诱导的条件性位置偏爱（CPP）的获得和表达的影响在雄性Wistar大鼠中进行了调查。每天接受3次皮下（s.c.）吗啡（1-9 mg / kg）或生理盐水（1.0 ml / kg）注射的动物表明，隔室与吗啡以剂量依赖的方式明显配对。用无效剂量的吗啡（1 mg / kg，皮下注射）对NMDA（0.01、0.1或1杯/大鼠）进行CeA内给药引起了显着的CPP。将非竞争性NMDA受体拮抗剂MK-801（0.1、0.3或0.5杯/大鼠）给药至杏仁核中央，可剂量依赖性地抑制吗啡（6 mg / kg，s.c.）诱导的位置偏爱。此外，MK-801的CeA内给药（0.25、0.5或1个杯子/大鼠）降低了NMDA（1个杯子/大鼠，CeA内）加吗啡（1 mg / kg，皮下注射）诱导的反应。 NMDA和MK-801都不单独产生明显的位置偏好或位置厌恶。此外，在测试前，CeA内注射NMDA而不是MK-801显着增加了吗啡的表达（6 mg / kg，皮下）诱导的位置偏爱。在测试过程中，将NMDA或MK-801注入CeA对运动能力没有影响。这些结果表明中央杏仁核中的NMDA受体机制可能参与吗啡诱导的位置偏好的获取和表达。

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