Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.

Jana S; Maiti AK; Bagh MB; Banerjee K; Das A; Roy A; Chakrabarti S

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Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.

机译：多巴胺而不是3,4-二羟基苯乙酸（DOPAC）通过自氧化和线粒体催化的氧化成醌的产物抑制大脑呼吸链的活性：对帕金森氏病的影响。

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This study reveals that, in contrast to dopamine (DA), 3,4 dihydroxyphenylacetic acid (DOPAC) during in vitro incubation up to 2 h causes only marginal inhibition of rat brain mitochondrial respiratory chain activity, a minimal loss of protein free thiols and very little quinoprotein adduct formation. The damaging effects of DA on brain mitochondria are, however, conspicuous and apparently mediated by quinone oxidation products generated by autoxidation of DA as well as catalyzed by a mitochondrial activity, inhibitable by clorgyline (2.5-10 microM) and cyanide (1 mM).

机译：这项研究表明，与多巴胺（DA）相比，在长达2小时的体外温育过程中3,4二羟基苯乙酸（DOPAC）只会对大鼠脑线粒体呼吸链活性产生一定程度的抑制作用，对蛋白质游离硫醇的损失极小，并且很少有喹蛋白加合物形成。然而，DA对脑线粒体的破坏作用是显着的，并且显然是由DA的自氧化产生的醌氧化产物介导的，并由线粒体活性催化的，可被高粱碱（2.5-10 microM）和氰化物（1 mM）抑制。

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《Brain research》 |2007年第0期|共6页
作者
Jana S; Maiti AK; Bagh MB; Banerjee K; Das A; Roy A; Chakrabarti S;
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正文语种 eng
中图分类神经病学;
关键词
Brain; Quinone; Respiratory; Asymptomatic diagnosis of; Oxidation; 脑;

机译：脑;奎酮;呼吸;无症状;氧化;脑诊断;

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1. Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease. [J] . Jana S, Maiti AK, Bagh MB, Brain research . 2007,第0期

机译：多巴胺而不是3,4-二羟基苯乙酸（DOPAC）通过自氧化和线粒体催化的氧化成醌的产物抑制大脑呼吸链的活性：对帕金森氏病的影响。
2. Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC). Implications for Parkinson's disease. [J] . Nunes C, Almeida L, Laranjinha J Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2005,第3期

机译：一氧化氮和二羟基苯基乙酸（DOPAC）协同抑制脑线粒体呼吸。对帕金森氏病的影响。
3. Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: Implications for Parkinson's disease [J] . Khan FH, Sen T, Maiti AK, Biochimica et biophysica acta. Molecular basis of disease: BBA . 2005,第1a2期

机译：多巴胺氧化产物在延长的体外孵育过程中抑制大鼠脑线粒体电子传输链活性：对帕金森氏病的影响
4. PROTEOMIC ANALYSIS OF RAT BRAIN MITOCHONDRIA FOLLOWING EXPOSURE TO DOPAMINE QUINONE: IMPLICATIONS FOR PARKINSON’S DISEASE [O] . Victor S. Van Laar, April A. Dukes, Michael Cascio, -1

机译：多巴胺喹酮暴露后大鼠脑线粒体的蛋白质组学分析：对帕金森氏病的意义
5. Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: Implications for Parkinson's disease [O] . Hossain Khan Firoj, Sen Tanusree, Maiti Arpan Kumar, 2005

机译：多巴胺氧化产物在延长的体外孵育过程中抑制大鼠脑线粒体电子传输链活性：对帕金森氏病的影响

Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: implications in Parkinson's disease.

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