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首页> 外文期刊>Brain research >Rip immunoreactivity significantly decreases in the stratum oriens of hippocampal CA1 region after transient forebrain ischemia in gerbils.
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Rip immunoreactivity significantly decreases in the stratum oriens of hippocampal CA1 region after transient forebrain ischemia in gerbils.

机译：沙土鼠短暂性前脑缺血后，海马CA1区的纹状体中Rip免疫反应性显着降低。

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摘要

In the present study, we observed ischemia-related changes in Rip recognizing the promyelinating and myelinating oligodendrocytes in the hippocampus proper after 5 min of transient forebrain ischemia in gerbils. Rip immunoreactivity was significantly altered in the hippocampal CA1 region but not in the CA2/3 region after ischemic insult. In the sham-operated group, Rip immunoreactivity was shown in the cell bodies and processes of oligodendrocytes in all layers of the hippocampus proper. From 15 min to 2 days after ischemic insult, Rip immunoreactivity was similar to that of sham-operated group. Three days after ischemic insult, Rip-immunoreactive processes were tangled in the stratum oriens of the CA1 region, and Rip protein level decreased from this time after ischemia. Thereafter, Rip immunoreactivity was decreased time dependently in the CA1 region. Seven days after ischemic insult, Rip-immunoreactive processes were tangled and densely detected in the stratum oriens adjacent to the stratum pyramidale. In brief, these results indicate that the significant decrease of Rip immunoreactivity in processes in the stratum oriens of the hippocampal CA1 region occurs at late time after ischemia, and this decrease in Rip immunoreactivity may be associated with delayed neuronal death of CA1 pyramidal cells.
机译：在本研究中，我们观察到沙鼠的短暂性前脑缺血5分钟后，Rip识别与海马中的早髓和髓鞘少突胶质细胞相关的缺血相关变化。缺血性损伤后，海马CA1区的Rip免疫反应性显着改变，而CA2 / 3区则没有。在假手术组中，在海马体各层的细胞体和少突胶质细胞的过程中显示出Rip免疫反应性。缺血性损伤后15分钟至2天，Rip免疫反应性与假手术组相似。缺血性损伤后三天，Rip免疫反应过程在CA1区的原始层缠结，并且从缺血后的这段时间开始Rip蛋白水平下降。此后，Rip免疫反应性在CA1区的时间依赖性降低。缺血性损伤后第7天，Rip免疫反应过程纠缠在一起，并在与锥体层相邻的Oriens中密集地检测到。简而言之，这些结果表明，在缺血后的较晚时间，海马CA1区原始层的Rip免疫反应性显着降低，并且Rip免疫反应性的降低可能与CA1锥体细胞的神经元死亡延迟有关。

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