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首页> 外文期刊>Brain research >Brain stimulation reward is integrated by a network of electrically coupled GABA neurons.
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Brain stimulation reward is integrated by a network of electrically coupled GABA neurons.

机译：电刺激的GABA神经元网络整合了大脑刺激奖励。

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摘要

The neural substrate of brain stimulation reward (BSR) has eluded identification since its discovery more than a half-century ago. Notwithstanding the difficulties in identifying the neuronal integrator of BSR, the mesocorticolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain has been implicated. We have previously demonstrated that the firing rate of a subpopulation of gamma-aminobutyric acid (GABA) neurons in the VTA increases in anticipation of BSR. We show here that GABA neurons in the VTA, midbrain, hypothalamus, and thalamus of rats express connexin-36 (Cx36) gap junctions (GJs) and couple electrically upon DA application or by stimulation of the internal capsule (IC), which also supports self-stimulation. The threshold for responding for IC self-stimulation was the threshold for electrical coupling between GABA neurons, the degree of responding for IC self-stimulation was proportional to the magnitude of electrical coupling between GABA neurons, and GJ blockers increased the threshold for IC self-stimulation without affecting performance. Thus, a network of electrically coupled GABA neurons in the ventral brain may form the elusive neural integrator of BSR.
机译：自从半个多世纪前发现以来，大脑刺激奖赏（BSR）的神经底物一直未被发现。尽管在鉴定BSR的神经元整合剂方面存在困难，但已牵涉到起源于中脑腹侧被盖区（VTA）的中皮层皮质多巴胺（DA）系统。我们以前已经证明，在预期BSR中，VTA中的γ-氨基丁酸（GABA）神经元亚群的放电速率会提高。我们在这里显示，大鼠VTA，中脑，下丘脑和丘脑中的GABA神经元表达连接蛋白36（Cx36）间隙连接（GJs），并在DA应用或通过刺激内囊（IC）时电耦合自我刺激。对IC自刺激的反应阈值是GABA神经元之间电耦合的阈值，对IC自刺激的反应程度与GABA神经元之间电耦合的大小成比例，并且GJ阻滞剂增加了IC自刺激的阈值刺激而不影响性能。因此，腹侧大脑中的电耦合GABA神经元网络可形成BSR难以捉摸的神经整合器。

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