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首页> 外文期刊>Brain research >Unilateral cortical application of interleukin-1beta (IL1beta) induces asymmetry in fos, IL1beta and nerve growth factor immunoreactivity: implications for sleep regulation.
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Unilateral cortical application of interleukin-1beta (IL1beta) induces asymmetry in fos, IL1beta and nerve growth factor immunoreactivity: implications for sleep regulation.

机译：单侧皮质应用白介素1β（IL1beta）诱导fos，IL1beta和神经生长因子免疫反应性的不对称性：对睡眠调节的影响。

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摘要

Unilateral injection of interleukin-1 beta (IL1beta) into the somatosensory cortex enhances EEG slow wave activity ipsilaterally during non-rapid eye movement sleep [Yasuda, T., Yoshida, H., Garcia-Garcia, F., Kay, D., Krueger, J.M., 2005. Interleukin-1beta has a role in cerebral cortical state-dependent electroencephalographic slow-wave activity. Sleep 28, 177-184]. We show that a similar unilateral microinjection of IL1beta (10 ng) into layer VI or onto the surface of the primary somatosensory cortex induced increases in the neuronal activity marker, Fos, relative to the contralateral side that received saline or heat-inactivated IL1beta. When IL1beta was microinjected into layer VI, increases in Fos-immunoreactive nuclei were evident in layers II, III and VI of the somatosensory cortex and connected cortical regions, such as the endopiriform, secondary somatosensory, piriform and prefrontal cortex. Asymmetrical increases in Fos were also observed in subcortical regions, such as the reticular thalamus, which receives a main cortical projection, and hypothalamic regions implicated in sleep regulation, such as the ventrolateral preoptic area and dorsal median preoptic nucleus. Fos activation was not observed in many other brain regions. In the reticular thalamus and somatosensory cortex, the number of IL1beta-immunoreactive glial cells increased. Further, the number of NGF-immunoreactive cells in the primary somatosensory cortex and magnocellular preoptic nucleus increased on the IL1beta-injected side. These results are consistent with the hypothesis that sleep is initiated within the cortex after the local activation of specific cytokines and that whole organism sleep is coordinated via cortical connections with the subcortical sites.
机译：在非快速眼动睡眠过程中，向体感皮层单侧注射白介素-1β（IL1beta）可同侧增强脑电图慢波活动[Yasuda，T.，Yoshida，H.，Garcia-Garcia，F.，Kay，D.， Krueger，JM，2005年。白介素-1β在大脑皮质状态依赖性脑电图慢波活动中起作用。睡眠28，177-184]。我们显示，IL1beta（10 ng）进入VI层或主要体感皮层表面的类似单侧显微注射诱导神经元活动标记Fos的增加，相对于接受盐水或热灭活的IL1beta的对侧。当将IL1beta微注射到VI层中时，在体感皮质和连接的皮质区域（如内膜状，次级体感，梨状和前额叶皮质）的II，III和VI层中明显可见Fos免疫反应性核的增加。在皮层下区域，如接受主要皮层投射的网状丘脑，以及与睡眠调节有关的下丘脑区域，如腹侧前视区和背中正视前核，也观察到Fos的不对称增加。在其他许多大脑区域均未观察到Fos激活。在网状丘脑和体感皮层中，IL1β-免疫反应性神经胶质细胞的数量增加。此外，在注射IL1beta的一侧，初级体感皮层和大细胞视前核中的NGF免疫反应性细胞数量增加。这些结果与以下假设相符：在特定细胞因子的局部激活后，睡眠在皮质内启动，整个生物体的睡眠通过与皮质下部位的皮质连接来协调。

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