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首页> 外文期刊>Brain research >Intrastriatal administration of 5-aminolevulinic acid induces convulsions and body asymmetry through glutamatergic mechanisms.
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Intrastriatal administration of 5-aminolevulinic acid induces convulsions and body asymmetry through glutamatergic mechanisms.

机译：纹状体内5-氨基乙酰丙酸的给药通过谷氨酸能机制引起惊厥和身体不对称。

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摘要

The involvement of glutamatergic and GABAergic mechanisms in the behavioral effects induced by the intrastriatal injection of 5-aminolevulinic acid (ALA) (1-8 mgr;mol/2 mgr;l), a metabolite that accumulates in porphyrias, was evaluated. ALA administration to adult female rats increased locomotor activity, induced clonic convulsions and elicited dose-dependent body asymmetry assessed by the elevated body swing test. ALA-induced convulsions were prevented by intrastriatal preadministration of the glutamate antagonists, 6, 7-dinitroquinoxaline-2,3-dione (8 nmol/0.5 microl) or dizocilpine (2. 5 nmol/0.5 microl), but not by the GABA agonist, muscimol (46 pmol/0. 5 microl). Body asymmetry was prevented only by 6, 7-dinitroquinoxaline-2,3-dione pretreatment. A higher dose of muscimol (92 pmol/0.5 microl) prevented both ALA-induced convulsions and body asymmetry. However, this dose of muscimol induced motor biases, which make difficult to ascertain the involvement of GABA(A) receptors in ALA-induced behavioral effects. This study suggests that glutamatergic mechanisms underlie the ALA-induced convulsions and body asymmetry. The present results may be of value in understanding the physiopathology of the neurological dysfunction occurring in acute porphyrias.
机译：评价了谷氨酸能和GABA能机制参与纹状体内注射5-氨基乙酰丙酸（ALA）（1-8 mgr; mol / 2 mgr; l）（一种在卟啉症中积累的代谢物）引起的行为效应。成年雌性大鼠服用ALA可以增加运动能力，诱发阵挛性抽搐，并通过升高的身体摆动测试来评估其剂量依赖性的身体不对称性。纹状体内预先给予谷氨酸拮抗剂，6，7-二硝基喹喔啉-2,3-二酮（8 nmol / 0.5 microl）或dizocilpine（2. 5 nmol / 0.5 microl）可预防ALA引起的惊厥，但GABA激动剂则不能。 ，麝香酚（46 pmol/0.5微升）。仅通过6、7-二硝基喹喔啉-2,3-二酮预处理可防止身体不对称。较高剂量的麝香酚（92 pmol / 0.5 microl）可以防止ALA引起的惊厥和身体不对称。但是，此剂量的Muscimol会引起运动偏见，从而难以确定GABA（A）受体是否参与了ALA引起的行为影响。这项研究表明，谷氨酸能机制是ALA引起的惊厥和身体不对称的基础。目前的结果可能对了解急性卟啉症中发生的神经功能障碍的生理病理学具有价值。

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