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首页> 外文期刊>Brain research >Distribution of alpha 2-adrenoceptors in the human locus coeruleus.
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Distribution of alpha 2-adrenoceptors in the human locus coeruleus.

机译：α2肾上腺素受体在人类蓝斑中的分布。

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摘要

Recent reports of specific topographic patterns of cell loss in the locus coeruleus (LC) in psychiatric and neurologic disorders underscores the need for detailed neurochemical analyses of this cell group. In this study, the anatomical distribution of alpha 2-adrenoceptors and its relationship to the distribution of noradrenergic neurons in the human LC was studied. Quantitative autoradiography was used to assess the binding of [125I]p-iodoclonidine ([125I]PIC) to alpha 2-adrenoceptors coordinately with counts of neuromelanin-containing cells in tissue sections cryocut at 10-13 levels along the rostrocaudal axis of the LC. Pontine brain tissue was obtained postmortem from 7 subjects dying of natural or accidental causes, ranging in age from 26 to 78 years. Both the binding of [125I]PIC and number of neuromelanin-containing cells were differentially distributed along the LC axis (P < 0.01) with almost identical topographical patterns. The highest concentration of binding and the greatest number of neuromelanin-containing cells per section occurred near the middle portion of the nucleus. There was a significant correlation between the number of neuromelanin-containing cells per section and the specific binding of [125I]PIC at any particular level of the LC (r2 = 0.56; P < 0.0001). The highest and lowest amounts of [125I]PIC binding in the LC were observed in the youngest and oldest subjects, respectively, and this trend was parallelled by a significant negative correlation between the number of neuromelanin-containing cells at a given level and age (r2 = 0.85; P < 0.003). The uneven distribution of alpha 2-adrenoceptors in the LC demonstrates the importance of anatomical specificity when performing quantitative studies of LC protein chemistry in psychiatric and neurologic disorders.
机译：最近有关精神病和神经系统疾病中蓝斑轨迹（LC）细胞丢失的特定地形图的报道强调了对该细胞组进行详细神经化学分析的需要。在这项研究中，研究了α2-肾上腺素受体的解剖分布及其与人LC中去甲肾上腺素能神经元分布的关系。定量放射自显影技术用于评估[125I] p-iodoclonidine（[125I] PIC）与α2肾上腺素受体的结合，以及沿LC尾脑轴冷冻切片的组织切片中10-13含量的组织切片中含神经黑色素的细胞的数量。 。从7名因自然或偶然原因死亡的受试者死后获得桥脑组织，年龄在26至78岁之间。 [125I] PIC的结合和含有神经黑色素的细胞数量均沿LC轴差异分布（P <0.01），几乎具有相同的地形图。结合的最高浓度和每个切片中含有神经黑色素的细胞数量最多，发生在细胞核的中部附近。每切片中含有神经黑色素的细胞数量与LC的任何特定水平下[125I] PIC的特异性结合之间存在显着相关性（r2 = 0.56; P <0.0001）。在LC中，分别在最年轻和最老的受试者中观察到最高和最低的[125I] PIC结合量，并且这种趋势与给定水平和年龄下含神经黑色素的细胞数量之间显着的负相关性平行（ r2 = 0.85; P <0.003）。 LC中α2肾上腺素能受体的不均匀分布表明，在进行精神病和神经疾病中LC蛋白化学的定量研究时，解剖学特异性的重要性。

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