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首页> 外文期刊>Brain research >Ginkgo biloba extract improves spatial memory in rats mainly but not exclusively via a histaminergic mechanism.
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Ginkgo biloba extract improves spatial memory in rats mainly but not exclusively via a histaminergic mechanism.

机译：银杏叶提取物主要但并非仅通过组胺能机制改善大鼠的空间记忆。

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摘要

In order to clarify the mechanism of Ginkgo biloba extract (GBE) on learning and memory, we studied the effect of GBE on spatial memory deficits induced by diphenhydramine, pyrilamine and scopolamine using the eight-arm radial maze performance of rats, in comparison with donepezil. Total error (TE), reference memory error (RME) and working memory error (WME) were used as indices of spatial memory deficits. Both GBE and donepezil caused a potent antagonistic effect on the increase in TE, RME and WME induced by diphenhydramine. GBE and donepezil also antagonized scopolamine-induced spatial memory deficits. Although the antagonistic effect of GBE on pyrilamine-induced spatial memory deficits was weak, a significant difference was observed with TE and WME. However, donepezil caused no antagonistic effect on pyrilamine-induced memory deficits. From these findings, we concluded that the effects of GBE are mainly contributable to cholinergic activity and perhaps partly due to a histaminergic mechanism.
机译：为了阐明银杏叶提取物（GBE）对学习和记忆的作用机理，我们与多奈哌齐比较，利用大鼠的八臂放射状迷宫性能研究了GBE对苯海拉明，吡拉明和东pol碱引起的空间记忆缺陷的影响。 。总错误（TE），参考内存错误（RME）和工作内存错误（WME）被用作空间内存不足的指标。 GBE和多奈哌齐均对苯海拉明引起的TE，RME和WME的增加产生强力拮抗作用。 GBE和多奈哌齐也可以拮抗东pol碱引起的空间记忆障碍。尽管GBE对吡喃胺诱导的空间记忆缺陷的拮抗作用较弱，但在TE和WME上观察到了显着差异。但是，多奈哌齐对吡拉明引起的记忆缺陷没有拮抗作用。从这些发现，我们得出结论，GBE的作用主要归因于胆碱能活性，也许部分归因于组胺能机制。

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