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首页> 外文期刊>Brain research >Evaluation of combined fibroblast growth factor-2 and moderate hypothermia therapy in traumatically brain injured rats.
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Evaluation of combined fibroblast growth factor-2 and moderate hypothermia therapy in traumatically brain injured rats.

机译：评价成纤维细胞生长因子2和中度低温疗法在脑外伤大鼠中的结合作用。

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Both the exogenous administration of fibroblast growth factor-2 (FGF-2) or the induction of moderate hypothermia have been shown to attenuate histopathology and improve functional outcome after traumatic brain injury (TBI). Since combined therapeutic strategies may be more beneficial than single therapies, we examined the potential synergistic effect of FGF-2 combined with moderate hypothermia treatment induced 10 min after TBI on functional and histological outcome following controlled cortical impact (CCI) injury. Fifty male Sprague-Dawley rats were randomized to one sham and four CCI treatment groups: Sham+vehicle (VEH); FGF-2 (45 microg/kg/h for 3 h i.v.)+Normothermia (37+/-0.5 degrees C); FGF-2+Hypothermia (32+/-0.5 degrees C for 3 h); VEH+Norm; VEH+Hypo. Vestibulomotor performance on the beam balance and beam-walk (BW) tasks on post-operative days 1-5 and spatial memory acquisition in the Morris water maze (MWM) on days 14-18 were assessed. After 4 weeks survival, histological evaluations (CA(1) and CA(3) cell counts and lesion volume) were performed. MWM performance improved in all treatment groups, but combined treatment was not more efficacious than either alone. The FGF-2+Hypo group performed significantly better than the other injured treatment groups in the BW task. Lastly, no significant group differences in beam balance or histological outcome were observed. These data suggest a suboptimal and incomplete synergy of combined FGF-2 and hypothermia treatment. These data may indicate that either our dose of FGF-2 or combination therapy was not optimized in our model.
机译：外源性成纤维细胞生长因子2（FGF-2）的施用或中度低温的诱导均显示可减轻组织损伤并改善颅脑损伤（TBI）后的功能结局。由于联合治疗策略可能比单一疗法更有益，因此我们研究了FGF-2联合TBI后10分钟诱导的中度低温治疗对受控的皮质撞击（CCI）损伤后功能和组织学结果的潜在协同作用。将五十只雄性Sprague-Dawley大鼠随机分为一个假手术和四个CCI治疗组：假手术+载体（VEH）;假手术+假手术（VEH）。 FGF-2（45 microg / kg / h静脉内3 h）+体温正常（37 +/- 0.5摄氏度）; FGF-2 +体温过低（32 +/- 0.5摄氏度，持续3小时）; VEH +规范; VEH + Hypo。评估了术后1-5天在束平衡和束行走（BW）任务上的动静性能，以及在14-18天在莫里斯水迷宫（MWM）中获得的空间记忆。存活4周后，进行组织学评估（CA（1）和CA（3）细胞计数和病变体积）。在所有治疗组中，MWM的表现均得到改善，但联合治疗的效果并不比单独治疗有效。在BW任务中，FGF-2 + Hypo组的表现明显优于其他受伤的治疗组。最后，在束平衡或组织学结果上没有观察到显着的组差异。这些数据表明，FGF-2与体温过低联合治疗的协同效果欠佳且不完全。这些数据可能表明我们的模型中未优化FGF-2剂量或联合治疗。

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