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首页> 外文期刊>Brain research >Effect of a 5-HT(1A) receptor agonist, flesinoxan, on the extracellular noradrenaline level in the hippocampus and on the locomotor activity of rats.
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Effect of a 5-HT(1A) receptor agonist, flesinoxan, on the extracellular noradrenaline level in the hippocampus and on the locomotor activity of rats.

机译：5-羟色胺（1A）受体激动剂flesinoxan对海马中细胞外去甲肾上腺素水平和大鼠运动能力的影响。

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摘要

We have studied effects of 5-hydroxytryptamine 1A (5-HT(1A)) receptor-selective compounds on the extracellular noradrenaline (NA) level in the hippocampus of rats using microdialysis and on their locomotor activity. A selective 5-HT(1A) receptor agonist, flesinoxan (5 mg/kg, i.p.) increased the extracellular NA level in the hippocampus, and increased the locomotor activity. Both responses were blocked by pretreatment with a 5-HT(1A) receptor antagonist, WAY100635 (1 mg/kg, i.p.) and an alpha(2) adrenoceptor agonist, clonidine (50 microg/kg, i.p.). Bilateral intrahippocampal injection of flesinoxan (200 nmol in 2 microl, respectively) increased the locomotor activity of rats and the intrahippocampal perfusion of flesinoxan (1 mM, 2 microl/min) increased the extracellular NA level in the hippocampus. Bilateral intrahippocampal injections of a small amount of WAY100635 (0.1 nmol in 2 microl, respectively) blocked the flesinoxan (5 mg/kg, i.p.)-induced hyperactivity. Flesinoxan (5 mg/kg, i.p.) did not significantly influence the level of serotonin or its major metabolite in the hippocampus, or dopamine or its metabolites in the striatum. In conclusion, these behavioral as well as pharmacological results indicate that postsynaptic 5-HT(1A) receptor activation by flesinoxan increase the extracellular NA level in the hippocampus, which may be the cause of the increase of the locomotor activity.
机译：我们已经使用微透析研究了5-羟色胺1A（5-HT（1A））受体选择性化合物对大鼠海马细胞内去甲肾上腺素（NA）水平的影响及其运动活性。选择性5-HT（1A）受体激动剂flesinoxan（5 mg / kg，i.p.）增加了海马中细胞外NA的水平，并增加了运动活性。两种反应均被5-HT（1A）受体拮抗剂WAY100635（1 mg / kg，i.p.）和α（2）肾上腺素受体激动剂可乐定（50 microg / kg，i.p.）预处理阻断。海马海藻酸钠的双侧注射（分别为2微升200 nmol）增加了大鼠的运动能力，海马海藻酸钠的海内灌注（1 mM，2微升/分钟）提高了海马的细胞外NA水平。海马双侧注射少量WAY100635（分别为0.1微摩尔浓度为2微升的海洛因）阻断了flesinoxan（5 mg / kg，i.p.）诱导的机能亢进。 Flesinoxan（5 mg / kg，i.p.）对海马中5-羟色胺或其主要代谢产物或纹状体中的多巴胺或其代谢产物的含量没有显着影响。总之，这些行为以及药理结果表明，通过flesinoxan激活的突触后5-HT（1A）受体会增加海马中的细胞外NA水平，这可能是运动活动增加的原因。

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