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首页> 外文期刊>Brain research >Ontogenesis of morphine-induced behavior in the cat.
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Ontogenesis of morphine-induced behavior in the cat.

机译：猫体内吗啡诱导行为的本体发生。

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We analyzed the behavioral responses to a single dose of morphine in kittens at postnatal (P) ages 7, 15, 30, 60, 90, and 120 days. Each kitten received 0.5 or 3.0 mg/kg i.p. of morphine sulphate or saline vehicle. An average of 6.5 kittens were studied at each dose and age. An ethogram was constructed, based on morphine effects in adult cats, to score appropriate behaviors from direct observation and video sampling. After injection behaviors were sampled for periods of 2 min every 15-30 min for a total of 4 h. The frequency of each selected behavior was scored at 2 s intervals during each of the 2 min periods and it was expressed as a percent of all time samples scored for the 4 h period. Statistical comparisons were made with control (saline) littermates. At P7-15 the drug's main effect was behavioral depression; i.e., kittens, away from the litter, laid sprawled as if with no muscle tonus; Nursing was suppressed and Vocalization was distressed. Mainly with the higher dose, at P30, morphine-specific behaviors appeared for the first time. With the kitten in a Sitting position, these included stereotypical Head and Paw Movements and body Torsion. At P60 other drug-elicited behaviors emerged, including Spinning, Retching, and Vomiting. By P90-120 the frequency of Head (16.0%) and Paw (16.9%) Movements doubled relative to P30-60. Morphine significantly changed frequencies of newly matured behaviors (in control kittens) including Sniffing and Licking (increased), and Grooming (decreased/blocked). Retching and Vomiting increased to adult levels. Morphine-induced hyperthermia was first detected at P60 and peaked by P90-P120. The early behavioral depression shifted to a pattern of increasing activity starting at P30 and peaking at P90-120, at which time Sleep was absent and Laying was reduced, while Walking and Sitting were increased. We concluded that the maturation of the stereotypical behavioral responses to morphine in cats begins at about P30 and is completed between P90 and 120. Results are discussed in terms of developmental parameters and putative brain sites of morphine's actions.
机译：我们分析了出生后（P）7、15、30、60、90和120天时对单剂量吗啡的小猫的行为反应。每只小猫腹腔接受0.5或3.0 mg / kg。硫酸吗啡或生理盐水。在每个剂量和年龄下平均研究了6.5只小猫。根据吗啡对成年猫的影响，构建了一个心电图，以通过直接观察和视频采样对适当的行为进行评分。注射后，每15-30分钟取样2分钟，共4小时。在2分钟的时间段内，每隔2 s间隔对每种选定行为的频率进行评分，并表示为在4小时内评分的所有时间样本的百分比。与对照（盐水）同窝仔进行统计学比较。在P7-15时，该药物的主要作用是行为抑郁。就是说，小猫远离垃圾，躺在地上，好像没有肌肉刺。护理受到压制，发声困难。主要在P30剂量较高时，首次出现吗啡特异性行为。当小猫处于坐姿时，这些动作包括定型的头爪动作和身体扭转。在P60，出现了其他毒品引发的行为，包括旋转，抓取和呕吐。到P90-120时，头部（16.0％）和爪（16.9％）的移动频率相对于P30-60翻了一番。吗啡显着改变了新成熟行为的频率（在对照组中），包括嗅和舔（增加）和修饰（减少/阻止）。呕吐和呕吐增加到成人水平。吗啡诱导的体温过高首先在P60检测到，并在P90-P120达到峰值。早期的行为抑郁症从P30开始转变为活动增加的模式，并在P90-120达到峰值，这时睡眠消失，躺着减少，而步行和坐着增加。我们得出的结论是，猫对吗啡的定型行为反应成熟于大约P30开始，并在P90和120之间完成。结果根据吗啡作用的发育参数和假定的脑部位进行了讨论。

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