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首页> 外文期刊>Brain research >Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.
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Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.

机译：多系统萎缩患者中神经胶质细胞质包裹物中Hsc70和Hsp70的积累。

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Heat shock proteins (HSPs) are molecular chaperones which can be induced by several kinds of stresses, and Hsc70 and Hsp70 are two major members of the family of 70 kDa HSPs. A major component of Lewy bodies (LBs) is alpha-synuclein, and Hsp70 has been observed in the LBs of brains with Parkinson's disease. Hsp70 has also been demonstrated to have the ability to suppress alpha-synuclein toxicity in vitro and in vivo. To investigate the precise role of Hsc70 and Hsp70 in patients with multiple system atrophy (MSA), which is another alpha-synuclein-related disease, we performed immunohistochemical studies on Hsc70 and Hsp70 using autopsied brains from 7 normal subjects and 15 patients with MSA. In the normal human brains, both neurons and glial cells, including oligodendrocytes, showed only weak Hsc70 and Hsp70 immunoreactivities. In contrast, in the brains with MSA, numerous glial cytoplasmic inclusions (GCIs) were intensely immunostained with Hsc70, and strong Hsc70 immunoreactivity was also found in glial intranuclear inclusions (GNIs), neuronal cytoplasmic inclusions (NCIs) and neuronal intranuclear inclusions (NNIs) as well as dystrophic neurites. The immunolabeling pattern for Hsp70 in the MSA brains was slightly different from that of Hsc70, and Hsp70 immunoreactivity was observed in many reactive astrocytes as well as some glial and neuronal inclusions. Our results suggest that the widespread accumulation of Hsc70 and Hsp70 may occur in brains with MSA, and that Hsc70 and Hsp70 may be associated with the pathogenesis of MSA.
机译：热休克蛋白（HSP）是分子伴侣，可以通过多种压力诱导，Hsc70和Hsp70是70 kDa HSP家族的两个主要成员。路易小体（LB）的主要成分是α-突触核蛋白，在患有帕金森氏病的大脑的LB中已观察到Hsp70。还已经证明Hsp70具有在体外和体内抑制α-突触核蛋白毒性的能力。为了研究Hsc70和Hsp70在另一种与α-突触核蛋白相关的疾病多系统萎缩（MSA）患者中的确切作用，我们使用来自7名正常受试者和15名MSA患者的尸检大脑对Hsc70和Hsp70进行了免疫组织化学研究。在正常的人脑中，神经元和神经胶质细胞（包括少突胶质细胞）仅显示弱的Hsc70和Hsp70免疫反应性。相反，在患有MSA的大脑中，许多神经胶质细胞质内含物（GCI）被Hsc70强烈免疫染色，并且在神经胶质细胞核内含物（GNI），神经元细胞质内含物（NCI）和神经元细胞核内含物（NNI）中也发现了强Hsc70免疫反应性。以及营养不良的神经突。 MSA脑中Hsp70的免疫标记模式与Hsc70略有不同，并且在许多反应性星形胶质细胞以及一些神经胶质和神经元包涵体中观察到Hsp70免疫反应性。我们的结果表明，Hsc70和Hsp70的广泛积累可能发生在MSA的大脑中，并且Hsc70和Hsp70可能与MSA的发病机理有关。

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