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首页> 外文期刊>Infection >Prevalence of Enterotoxin Producing Staphylococcus aureus in Stools of Patients with Nosocomial Diarrhea.
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Prevalence of Enterotoxin Producing Staphylococcus aureus in Stools of Patients with Nosocomial Diarrhea.

机译：院内腹泻患者粪便中产生肠毒素的金黄色葡萄球菌的患病率。

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BACKGROUND: Nosocomial diarrhea causes prolonged hospital stay leading to additional diagnostic and therapeutic procedures resulting in higher costs. A total of 20%-25% of antibiotic-associated diarrhea (AAD) cases are attributed to Clostridium difficile. Other microorganisms like Clostridium perfringens and Staphylococcus aureus are discussed to be associated with AAD. PATIENTS AND METHODS: This study evaluated the prevalence of enterotoxigenic S. aureus in stool samples submitted to the laboratory with the diagnosis nosocomial diarrhea. A total of 2,727 stools from clinical patients were investigated for S. aureus and C. difficile. Samples were cultured for both bacteria and a C. difficile toxin A and B assay was performed from all stools. Isolated S. aureus were investigated for enterotoxin production and for resistance against methicillin. In addition, both assays were evaluated for determination of S. aureus enterotoxins directly in stool samples. RESULTS: Out of 2,727 stools investigated, 198 grew S. aureus and 148 C. difficile. Toxins A/B from C. difficile were detected in 184 stools. A total of 114 S. aureus strains produced the following enterotoxins in vitro: A, 36; B, 20; C, 19; D, 68; E, 2. Both pathogens were found in 25 stools. Twenty-nine (14.6%) S. aureus strains were identified as methicillin-resistant. The two toxin assays evaluated in this study were not able to detect S. aureus enterotoxins directly in stools. CONCLUSION: The role of enterotoxigenic S. aureus in the pathogenesis of nosocomial and AAD needs further consideration. It might be necessary to investigate stool samples from patients with AADosocomial diarrhea for S. aureus on a routine basis.
机译：背景：医院腹泻会导致住院时间延长，从而导致额外的诊断和治疗程序，从而导致更高的费用。总共20％-25％的抗生素相关性腹泻（AAD）病例归因于艰难梭菌。讨论了其他产气荚膜梭菌和金黄色葡萄球菌等微生物与AAD的关系。患者与方法：本研究评估了呈实验室诊断为粪便的粪便样品中肠毒素性金黄色葡萄球菌的流行情况。对来自临床患者的总共2727份粪便进行了金黄色葡萄球菌和艰难梭菌调查。培养样品中的两种细菌，并从所有粪便中进行艰难梭菌毒素A和B测定。研究了分离的金黄色葡萄球菌的肠毒素产生和对甲氧西林的抗性。另外，评估了两种测定法，以直接测定粪便样品中的金黄色葡萄球菌肠毒素。结果：在研究的2727份粪便中，有198株生长的金黄色葡萄球菌和148株艰难梭菌。在184个粪便中检测到了艰难梭菌毒素A / B。总共114种金黄色葡萄球菌菌株在体外产生以下肠毒素：A，36; A，36; A，36。 B，20; C，19; D，68; E，2.在25个粪便中发现了两种病原体。鉴定出二十九（14.6％）的金黄色葡萄球菌菌株对甲氧西林具有抗性。在这项研究中评估的两种毒素测定法不能直接在粪便中检测到金黄色葡萄球菌肠毒素。结论：产肠毒素的金黄色葡萄球菌在医院和AAD发病机制中的作用还需要进一步考虑。可能有必要常规检查AAD /医院腹泻患者的粪便样本是否为金黄色葡萄球菌。

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