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首页> 外文期刊>Brain research >Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide.
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Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide.

机译：帕夫洛夫恐惧症的获得，灭绝和恢复：NMDA受体和一氧化氮的作用。

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摘要

The acquisition and extinction of Pavlovian conditioned fear have been shown to be mediated by the N-methyl-D-aspartate (NMDA) glutamate receptor. This study found that the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) blocked the reinstatement of Pavlovian conditioned fear in rats. The role of nitric oxide (NO) in the acquisition and extinction of Pavlovian fear conditioning was also examined. L-NAME, an NO synthase inhibitor, failed to block the acquisition or extinction of Pavlovian fear conditioning. The results are discussed in the context of hierarchical associations and the array of NMDA and calcium mediated mechanisms of synaptic strengthening.
机译：帕夫洛夫病的恐惧感的获得和消退已被证明是由N-甲基-D-天冬氨酸（NMDA）谷氨酸受体介导的。这项研究发现，NMDA拮抗剂（+）-5-甲基-10,11-二氢-5H-二苯并[a，d]环庚-5,10-亚胺马来酸酯（MK-801）阻止了巴甫洛夫病的恢复对老鼠的恐惧。还检查了一氧化氮（NO）在巴甫洛夫式恐惧调节的获得和灭绝中​​的作用。 NO合酶抑制剂L-NAME未能阻止巴甫洛夫恐惧条件的获得或灭绝。在分级关联和NMDA阵列以及钙介导的突触增强机制的背景下讨论了结果。

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