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首页> 外文期刊>Infection >Endocarditis due to Aerococcus urinae: diagnostic tests, fatty acid composition and killing kinetics.
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Endocarditis due to Aerococcus urinae: diagnostic tests, fatty acid composition and killing kinetics.

机译：因小球菌引起的心内膜炎：诊断测试，脂肪酸组成和杀伤动力学。

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摘要

Two cases of Aerococcus urinae endocarditis are reported. The organism is not included in any database of commercial identification systems at this time. Formation of tetrades and positive reactions for leucine arylamidase and beta-glucuronidase pointed strongly to A. urinae. The cellular fatty acid pattern was similar to that of Aerococcus viridans, with predominantly C16:0, C18:1 omega 9c and C18:0; the presence of C18:1 omega 7t differentiated our isolates from A. viridans and can support the diagnosis of A. urinae. Furthermore, susceptibility to penicillin but resistance to cotrimoxazole represents a pattern opposite to that of A. viridans. Minimal inhibition concentrations of gentamicin and netilmicin were < or = 64 mg/l but those of tobramycin were > or = 256 mg/l. Penicillin combined with either gentamicin or netilmicin showed distinct synergy in killing kinetics. These combinations seem to be the appropriate regimen to treat A. urinae endocarditis.
机译：据报道有2例小球菌性心内膜炎。目前，该生物不包含在任何商业识别系统数据库中。亮氨酸芳基酰胺酶和β-葡糖醛酸糖苷酶的四分体的形成和阳性反应强烈提示了尿曲霉。细胞脂肪酸模式与绿球菌相似，主要为C16：0，C18：1Ω9c和C18：0; C18：1欧米茄7t的存在将我们的分离株与绿假单胞菌区分开来，并且可以支持尿小曲霉的诊断。此外，对青霉素的敏感性但对考特莫唑的抗性表现出与绿色拟青霉相反的模式。庆大霉素和奈替米星的最小抑菌浓度为<或= 64 mg / l，但妥布霉素的抑菌浓度为>或= 256 mg / l。青霉素联合庆大霉素或奈替米星在杀灭动力学上显示出明显的协同作用。这些组合似乎是治疗尿道心内膜炎的合适方案。

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