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首页> 外文期刊>Infection >Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.
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Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.

机译：在选定的高热性中性粒细胞减少性癌症患儿中，静脉内经验性抗生素治疗的短期课程。

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BACKGROUND: Since the optimal duration of antibiotic therapy in febrile neutropenic patients is not clear, we evaluated the safety and efficacy of short courses of intravenous antibiotic treatment in selected pediatric cancer patients admitted for fever and neutropenia. PATIENTS AND METHODS: We retrospectively analyzed the clinical course of children with chemotherapy-induced neutropenia and fever. All patients were treated with empirical intravenous antibiotics. In episodes of fever of unknown origin (FUO), treatment regimen allowed discontinuation of antibiotics and early hospital discharge regardless of absolute neutrophil count (ANC) or evidence of bone marrow recovery as long as patients were afebrile for at least 24 h and had been treated for a minimum of 72 h. RESULTS: 106 episodes of febrile neutropenia occurred in 56 patients. 84 episodes were classified as FUO and intravenous antibiotic therapy was discontinued regardless of ANC when patients met the criteria described above. No death or major complication occurred. None of the patients had to be rehospitalized for recurrent fever or infection. CONCLUSION: Discontinuation of intravenous antibiotics regardless of ANC or evidence of bone marrow recovery seems safe and effective in pediatric cancer patients with FUO when children are afebrile for at least 24 h and are treated for a minimum of 72 h.
机译：背景：由于对发热性中性粒细胞减少症患者的最佳抗生素治疗时间尚不清楚，因此我们评估了入院发烧和中性粒细胞减少症的部分儿科癌症患者短期静脉使用抗生素治疗的安全性和有效性。病人和方法：我们回顾性分析了儿童化疗引起的中性粒细胞减少和发烧的临床过程。所有患者均接受了经验性静脉内抗生素治疗。在不明原因的发烧（FUO）发作中，只要患者至少有24小时发热并且已经接受治疗，无论绝对中性粒细胞计数（ANC）或骨髓恢复的证据如何，治疗方案均允许停用抗生素并尽早出院至少持续72小时。结果：56例患者发生106例高热性中性粒细胞减少。当患者符合上述标准时，将84例事件归为FUO，并且无论ANC均停止静脉内抗生素治疗。没有死亡或严重并发症发生。无需为再次发烧或感染而重新住院。结论：无论患儿是否发热至少24 h，并且接受至少72 h的治疗，无论是否使用ANC或停用骨髓恢复的证据，都应停止静脉抗生素治疗，对于小儿FUO的患者似乎是安全有效的。

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