Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis.

Kato H.; Jochim R. C.; Gomez E. A.; Uezato H.; Mimori T.; Korenaga M.; Sakurai T.; Katakura K.; Valenzuela J. G.; Hashiguchi Y.

首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis.

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Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis.

机译：沙蝇Lutzomyia ayacuchensis（一种安第斯型皮肤利什曼病的载体）的唾液腺转录本分析。

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The saliva of blood sucking insects contains potent pharmacologically active components that assist them in counteracting the host hemostatic and inflammatory systems during blood feeding. In addition, sand fly salivary proteins affect host immunity and have the potential to be a vaccine against Leishmania infection. In the present study, the salivary gland transcripts of Lutzomyia ayacuchensis, a vector of cutaneous leishmaniasis in Ecuadorian and Peruvian Andes, were analyzed by sequencing randomly selected clones of the salivary gland cDNA library of this sand fly. This resulted in the identification of the most abundant transcripts coding for secreted proteins. These proteins were homologous to the salivary molecules present in other sand flies including the RGD-containing peptide, PpSP15/SL1 family protein, yellow-related protein, putative apyrase, antigen 5-related protein, D7 family protein, and 27 kDa salivary protein. Of note, homologues of maxadilan, an active vasodilator abundantly present in saliva of Lutzomyia longipalpis, were not identified. This analysis is the first description of salivary proteins from a sand fly of the subgenus Helcocyrtomyia and from vector of cutaneous leishmaniasis in the New World. The present analysis will provide further insights into the evolution of salivary components in blood sucking arthropods.

机译：吸血昆虫的唾液中含有有效的药理活性成分，可帮助它们在采血期间抵抗宿主的止血和炎症系统。此外，沙蝇唾液蛋白会影响宿主免疫力，并有可能成为抵抗利什曼原虫感染的疫苗。在本研究中，通过随机选择该沙蝇唾液腺cDNA文库的克隆，分析了Lutzomyia ayacuchensis的唾液腺转录本，厄瓜多尔和秘鲁安第斯山脉的皮肤利什曼病的载体。这导致鉴定出编码分泌蛋白的最丰富的转录本。这些蛋白与存在于其他沙蝇中的唾液分子同源，包括含RGD的肽，PpSP15 / SL1家族蛋白，黄色相关蛋白，假定的腺苷三磷酸酶，抗原5相关蛋白，D7家族蛋白和27 kDa唾液蛋白。值得注意的是，未鉴定出长足的Lutzomyia longipalpis唾液中大量存在的一种活性血管扩张剂马他地兰的同系物。该分析是对新大陆中Helicocyrtomyia属的沙蝇和皮肤利什曼病的媒介唾液蛋白的首次描述。本分析将为吸血节肢动物唾液成分的演变提供进一步的见解。

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《Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases》 |2013年第null期|共11页
作者
Kato H.; Jochim R. C.; Gomez E. A.; Uezato H.; Mimori T.; Korenaga M.; Sakurai T.; Katakura K.; Valenzuela J. G.; Hashiguchi Y.;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
Lutzomyia ayacuchensis; Salivary gland; Transcript; Bioinformatics; cDNA library;

机译：扁桃体;唾液腺;转录本;生物信息学;cDNA文库;

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1. Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis. [J] . Kato H., Jochim R. C., Gomez E. A., Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2013,第Null期

机译：沙蝇Lutzomyia ayacuchensis（一种安第斯型皮肤利什曼病的载体）的唾液腺转录本分析。
2. Distribution of Lutzomyia ayacuchensis, the vector of Andean-type cutaneous leishmaniasis, at different altitudes on the Andean slopi Ecuador [J] . Eduardo A. Gomez, Hirotomo Kato, Tatsuyuki Mimori, Acta tropica: Journal of Biomedical Sciences . 2014,第Null期

机译：安第斯山脉厄瓜多尔不同海拔高度的安第斯型皮肤利什曼病的媒介-夜蛾Lutzomyia ayacuchensis的分布
3. Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi [J] . Valenzuela JG, Garfield M, Rowton ED, The Journal of Experimental Biology . 2004,第21期

机译：从沙蝇Lutzomyia longipalpis（利什曼原虫Chagasi的载体）唾液腺中鉴定出最丰富的分泌蛋白
4. Transcriptome (RNA-seq) analysis of human salivary gland cells with exogenous expression of human pancreas beta cells transcription factors PDX1, MAFA, NGN3 [C] . Olga Brovkina, Yulia Kolesova, Mikhail Borisov, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：外源表达人胰腺β细胞转录因子PDX1，MAFA，NGN3的人唾液腺细胞的转录组（RNA-seq）分析
5. Defining the ecology of the sand fly, Lutzomyia verrucarum (Diptera: Psychodidae) using population genetics and geographic information systems. [D] . Cohnstaedt, Lee William. 2009

机译：利用种群遗传学和地理信息系统确定沙蝇的生态学，即Lutzomyia verrucarum（Diptera：Psychodidae）。
6. Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis a vector of Andean-type cutaneous leishmaniasis [O] . Hirotomo Kato, Ryan C. Jochim, Eduardo A. Gomez, -1

机译：分析沙蝇液血糖成绩单AyacuchensisAndean型皮肤林氏菌载体
7. Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis [O] . Kato, Hirotomo, Jochim, Ryan C., Gomez, Eduardo A., 2013

机译：沙蝇Lutzomyia ayacuchensis（一种安第斯型皮肤利什曼病的载体）的唾液腺转录本分析
8. Sand Fly Salivary Protein Vaccine Shows Efficacy Against Vector-Transmitted Cutaneous Leishmaniasis in Nonhuman Primates. [R] . Oliveira, F., Rowton, E., Aslan, H., 2015

机译：沙蝇唾液蛋白疫苗显示非人灵长类动物对载体传播的皮肤利什曼病的功效。

Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis.

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