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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Transmission probabilities and durations of immunity for three pathogenic group B Streptococcus serotypes
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Transmission probabilities and durations of immunity for three pathogenic group B Streptococcus serotypes

机译：三种B型病原链球菌血清型的传播概率和免疫持续时间。

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摘要

Group B Streptococcus (GBS) remains a major cause of neonatal sepsis and is an emerging cause of invasive bacterial infections. The 9 known serotypes vary in virulence, and there is little cross-immunity. Key parameters for planning an effective vaccination strategy, such as average length of immunity and transmission probabilities by serotype, are unknown. We simulated GBS spread in a population using a computational model with parameters derived from studies of GBS sexual transmission in a college dormitory. Here we provide estimates of the duration of immunity relative to the transmission probabilities for the 3 GBS serotypes most associated with invasive disease: Ia, III, and V. We also place upper limits on the durations of immunity for serotype la (570 days), III (1125 days) and V (260 days). Better transmission estimates are required to establish the epidemiological parameters of GBS infection and determine the best vaccination strategies to prevent GBS disease
机译：B组链球菌（GBS）仍然是新生儿败血症的主要原因，也是侵入性细菌感染的新兴原因。 9种已知的血清型的毒力各不相同，并且几乎没有交叉免疫。计划有效疫苗接种策略的关键参数，例如平均免疫力长度和按血清型的传播概率是未知的。我们使用计算模型模拟了GBS在人群中的传播，该模型的参数来自大学宿舍中GBS性传播的研究。在这里，我们提供了与3种与侵袭性疾病最相关的GBS血清型的传播概率相关的免疫持续时间的估计值。我们还对血清型1a（570天）的免疫持续时间设置了上限， III（1125天）和V（260天）。需要更好的传播估计来确定GBS感染的流行病学参数并确定预防GBS疾病的最佳疫苗接种策略

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