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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance
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Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance

机译：PTPN22 1858C / T基因多态性与结核病抗性之间的关联

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摘要

Previous studies identified the functional polymorphism 1858C/T in the gene PTPN22 in association with several autoimmune diseases and with resistance to tuberculosis (TB). This study is the first to investigate the association between pulmonary TB and the PTPN22 1858C/T polymorphism in the Brazilian Amazon. We conducted a case-control study involving a group of 413 individuals, comprised of 208 TB carriers and 205 controls. No significant association between the PTPN22 1858T allele frequency in controls (2.43!) and TB carriers (2.7%, p = 0.982, odds ratio (OR) = 0.89, 95% confidence interval = 0.37-2.13) was identified in the Brazilian Amazon population. An additional evaluation by meta-analysis, however, suggested a protective role of the T allelein relation to TB (pooled OR = 0.44, p = 0.011). These results suggest that the PTPN22 1858T allele serves as a protective genetic factor for TB in those individuals who carry this minor allele.
机译：先前的研究确定了基因PTPN22中的功能多态性1858C / T与几种自身免疫性疾病以及对结核病（TB）的抵抗有关。这项研究是首次调查巴西亚马逊地区肺结核与PTPN22 1858C / T多态性之间的关联。我们进行了一项病例对照研究，涉及413人，包括208 TB携带者和205例对照。在巴西亚马逊地区人群中，对照组（2.43！）的PTPN22 1858T等位基因频率与结核病携带者（2.7％，p = 0.982，优势比（OR）= 0.89，95％置信区间= 0.37-2.13）之间没有显着相关性。 。但是，通过荟萃分析进行的另一项评估表明，T等位蛋白与TB之间具有保护作用（合并OR = 0.44，p = 0.011）。这些结果表明，PTPN22 1858T等位基因可作为携带该次要等位基因的个体中TB的保护性遗传因子。

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