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首页> 外文期刊>Brain research bulletin >Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system
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Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system

机译：含分泌促泌素的神经元在小鼠基底前脑中的分布，特别涉及胆碱能皮质激素系统

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Cholinergic and GABAergic corticopetal neurons in the basal forebrain play important roles in cortical activation, sensory processing, and attention. Cholinergic neurons are intermingled with peptidergic, and various calcium binding protein-containing cells, however, the functional role of these neurons is not well understood. In this study we examined the expression pattern of secretagogin (Scgn), a newly described calcium-binding protein, in neurons of the basal forebrain. We also assessed some of the corticopetal projections of Scgn neurons and their co-localization with choline acetyltransferase (ChAT), neuropeptide-Y, and other calcium-binding proteins (i.e., calbindin, calretinin, and parvalbumin). Scgn is expressed in cell bodies of the medial and lateral septum, vertical and horizontal diagonal band nuclei, and of the extension of the amygdala but it is almost absent in the ventral pallidum. Scgn is co-localized with ChAT in neurons of the bed nucleus of the stria terminalis, extension of the amygdala, and interstitial nucleus of the posterior limb of the anterior commissure. Scgn was co-localized with calretinin in the accumbens nucleus, medial division of the bed nucleus of stria terminalis, the extension of the amygdala, and interstitial nucleus of the posterior limb of the anterior commissure. We have not found co-expression of Scgn with parvalbumin, calbindin, or neuropeptide-Y. Retrograde tracing studies using Fluoro Gold in combination with Scgn-specific immunohistochemistry revealed that Scgn neurons situated in the nucleus of the horizontal limb of the diagonal band project to retrosplenial and cingulate cortical areas.
机译：基底前脑的胆碱能和GABA能皮质皮质神经元在皮层激活，感觉处理和注意力中起重要作用。胆碱能神经元与肽能神经元和各种含钙结合蛋白的细胞混合在一起，但是，这些神经元的功能作用尚不清楚。在这项研究中，我们检查了分泌前蛋白（Scgn），一种新描述的钙结合蛋白在基底前脑神经元中的表达模式。我们还评估了Scgn神经元的某些皮质瓣投射及其与胆碱乙酰基转移酶（ChAT），神经肽Y和其他钙结合蛋白（即calbindin，calretinin和parvalbumin）的共定位。 Scgn在内侧和外侧间隔，垂直和水平对角带核以及杏仁核的延伸的细胞体中表达，但在腹侧苍白球中几乎不存在。 Scgn与ChAT共同位于终末皮层床核，杏仁核的延伸和前连合后肢的间质核的神经元中。 Scgn与钙网蛋白共定位在伏隔核，终末纹的床核内侧分裂，杏仁核的延伸和前连合后肢的间质核中。我们还没有发现Scgn与小白蛋白，钙结合蛋白或神经肽Y的共表达。使用Fluoro Gold结合Scgn特异性免疫组织化学进行的逆行追踪研究显示，位于对角带水平肢核中的Scgn神经元投射到脾后和扣带回皮质区域。

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