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首页> 外文期刊>Inflammatory bowel diseases >Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis.
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Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis.

机译：粪便中4种嗜中性粒细胞衍生蛋白的比较，作为溃疡性结肠炎疾病活动的指标。

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BACKGROUND: To evaluate the diagnostic use of fecal concentrations of lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil-elastase (PMN-e), and lysozyme (Lys) as indicators of disease activity in patients with active and inactive ulcerative colitis (UC). METHODS: A total of 76 fecal specimens were collected from 31 patients with UC in times of active and inactive status of disease. Disease activity was determined with the colitis activity index (CAI; Rachmilewitz index), which includes a combination of laboratory parameters and clinical symptoms, with a score of at least 6 indicating active disease. Fecal Lf, Cal, PMN-e, and Lys were measured and reported as micrograms per milliliter feces. Levels of more than 7.25, more than 6.00, at least 0.062, and at least 0.6 for Lf, Cal, PMN-e, and Lys, respectively, were considered elevated as specified by the manufacturers. RESULTS: Based on the CAI classification, 25 of the samples were from patients with active disease status and 51 were from patients with inactive status. Lf, PMN-e, and Cal but not Lys showed increased levels in samples from patients in active disease compared with those in remission (median for Lf: 28.12 +/- 110.86 versus 179.54 +/- 334.09, P < 0.001; median for Cal: 15.13 +/- 30.27 versus 116.23 +/- 182.29, P < 0.001; median for PMN-e: 0.21 +/- 0.44 versus 1.02 +/- 0.89, P < 0.001; median for Lys: 1.54 +/- 2.39 versus 3.75 +/- 5.39, P > 0.05). All 4 parameters correlated with the CAI (Lf: r = 0.441, P < 0.001; Cal: r = 0.505, P < 0.001; PMN-e: r = 0.604, P < 0.001; Lys: r = 0.295, P < 0.05). Introducing a composite index based on Lf, Cal, and PMN-e, the specificity was 72.5% and the sensitivity 88% compared with the CAI. CONCLUSIONS: Among the neutrophil-derived proteins in feces, PMN-e, Cal, and Lf represent useful markers of disease activity in patients with UC. Using all 3 markers in a composite index may be an additional noninvasive tool for the management of ambulant patients with UC.
机译：背景：为了评估粪便中乳铁蛋白（Lf），钙卫蛋白（Cal），多形核中性粒细胞弹性蛋白酶（PMN-e）和溶菌酶（Lys）的诊断用途，作为活动性和非活动性溃疡性结肠炎患者疾病活动的指标（ UC）。方法：从31名UC患者的活动状态和非活动状态收集了76份粪便标本。用结肠炎活动指数（CAI; Rachmilewitz指数）确定疾病活动，该指数包括实验室参数和临床症状的组合，得分至少为6表示活动性疾病。测量粪便中的Lf，Cal，PMN-e和Lys，并以每毫升粪便中的微克报告。根据制造商的规定，Lf，Cal，PMN-e和Lys的水平分别高于7.25，高于6.00，至少0.062和至少0.6。结果：根据CAI分类，其中25个样本来自疾病状态活跃的患者，51个样本来自疾病状态活跃的患者。 Lf，PMN-e和Cal而非Lys显示活动性疾病患者的样品水平与缓解期相比有所增加（Lf的中位数为28.12 +/- 110.86，而179.54 +/- 334.09，P <0.001; Cal的中位数：15.13 +/- 30.27与116.23 +/- 182.29，P <0.001; PMN-e的中位数：0.21 +/- 0.44与1.02 +/- 0.89，P <0.001; Lys的中位数：1.54 +/- 2.39与3.75 +/- 5.39，P> 0.05）。所有4个参数均与CAI相关（Lf：r = 0.441，P <0.001; Cal：r = 0.505，P <0.001; PMN-e：r = 0.604，P <0.001; Lys：r = 0.295，P <0.05） 。引入基于Lf，Cal和PMN-e的综合指数，与CAI相比，特异性为72.5％，灵敏度为88％。结论：在粪便中嗜中性粒细胞衍生蛋白中，PMN-e，Cal和Lf代表UC患者疾病活动的有用标志物。在综合指数中使用所有这三个标记可能是用于管理UC的门诊病人的另一种非侵入性工具。

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