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首页> 外文期刊>Inflammatory bowel diseases >Bone loss in Crohn's disease: exercise as a potential countermeasure.
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Bone loss in Crohn's disease: exercise as a potential countermeasure.

机译：克罗恩病的骨质流失：运动是一种潜在的对策。

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摘要

Crohn's disease (CD) is associated with a number of secondary conditions including osteoporosis, which increases the risk of bone fracture. The cause of metabolic bone disease in this population is believed to be multifactorial and may include the disease itself and associated inflammation, high-dose corticosteroid use, weight loss and malabsorption, a lack of exercise and physical activity, and an underlying genetic predisposition to bone loss. Reduced bone mineral density has been reported in between 5% to 80% of CD sufferers, although it is generally believed that approximately 40% of patients suffer from osteopenia and 15% from osteoporosis. Recent studies suggest a small but significantly increased risk of fracture compared with healthy controls and, perhaps, sufferers of other gastrointestinal disorders such as ulcerative colitis. The role of physical activity and exercise in the prevention and treatment of CD-related bone loss has received little attention, despite the benefits of specific exercises being well documented in healthy populations. This article reviews the prevalence of and risk factors for low bone mass in CD patients and examines various treatments for osteoporosis in these patients, with a particular focus on physical activity.
机译：克罗恩病（CD）与包括骨质疏松症在内的许多继发性疾病相关，这增加了骨折的风险。人们认为该人群中代谢性骨病的病因是多方面的，可能包括疾病本身和相关的炎症，高剂量皮质类固醇的使用，体重减轻和吸收不良，缺乏运动和体育锻炼以及潜在的遗传性骨易感性失利。据报道，CD患者的骨矿物质密度降低了5％至80％，尽管通常认为大约40％的患者患有骨质减少症，而15％的患者患有骨质疏松症。最近的研究表明，与健康对照组以及其他胃肠道疾病（如溃疡性结肠炎）患者相比，骨折风险较小但显着增加。尽管在健康人群中已充分证明了特定锻炼的益处，但是体育锻炼和锻炼在预防和治疗CD相关的骨丢失中的作用却鲜有关注。本文回顾了CD患者中骨质疏松的患病率和危险因素，并研究了这些患者中骨质疏松症的各种治疗方法，特别关注身体活动。

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