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首页> 外文期刊>Inflammatory bowel diseases >Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population.
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Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population.

机译：IL-18基因启动子多态性与日本人群炎症性肠病之间的关联。

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BACKGROUND: Interleukin-18 (IL-18) is a pleiotropic cytokine that induces the production of interferon (IFN)-gamma and also to regulate Th2 cytokines. Recently, association studies between IL-18 gene promoter polymorphisms and several Th1- or Th2-mediated inflammatory diseases were reported. In inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), recent evidence suggests that IL-18 is involved in the pathogenesis. METHODS: Using DNA direct sequencing, we investigated IL-18 gene promoter polymorphisms at -607C/A and -137G/C. Allele, genotype, and haplotype frequencies were determined in 210 Japanese patients with UC, 205 patients with CD, and 212 controls. RESULTS: In UC, the -137C allele frequency was significantly higher in the proctitis-type patients than in controls (Pc = 0.0068). The -137 genotype frequency was also significantly different in the proctitis-type patients than in controls (Pc = 0.032). No other allele and genotype frequencies were significantly associated with UC after Bonferroni correction. Furthermore, the frequency of haplotype 2 (-607A, -137C), which had a lower promoter activity and IFN-gamma mRNA level than the other haplotypes as previously reported, was significantly higher in the proctitis-type patients than in controls (Pc = 0.01). In CD, we could not find any significant differences. CONCLUSIONS: IL-18 gene promoter polymorphisms may not be associated with disease susceptibility but related to the extent of disease in UC.
机译：背景：白介素-18（IL-18）是一种多效性细胞因子，可诱导干扰素（IFN）-γ的产生并调节Th2细胞因子。近来，报道了IL-18基因启动子多态性与几种Th1-或Th2-介导的炎性疾病之间的关联研究。在炎症性肠病（IBD）中，包括溃疡性结肠炎（UC）和克罗恩氏病（CD），最近的证据表明IL-18参与了发病机理。方法：使用DNA直接测序，我们研究了IL-18基因启动子在-607C / A和-137G / C的多态性。在210名日本UC患者，205名CD患者和212名对照中确定了等位基因，基因型和单倍型频率。结果：在UC中，直肠炎型患者的-137C等位基因频率显着高于对照组（Pc = 0.0068）。直肠炎型患者的-137基因型频率也显着不同于对照组（Pc = 0.032）。 Bonferroni校正后，没有其他等位基因和基因型频率与UC显着相关。此外，直肠炎型患者的单倍型2（-607A，-137C）的启动子活性和IFN-γmRNA水平低于其他单倍型，其频率在直​​肠炎型患者中明显高于对照组（Pc = 0.01）。在CD中，我们找不到任何重大差异。结论：IL-18基因启动子多态性可能与疾病易感性无关，但与UC的疾病程度有关。

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