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首页> 外文期刊>Biomedical Research >Acute stress augments innate immunity in the liver and increases hyaluronanlevels in the tissues and blood of mice
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Acute stress augments innate immunity in the liver and increases hyaluronanlevels in the tissues and blood of mice

机译：急性应激会增强肝脏的先天免疫力，并增加小鼠组织和血液中的透明质酸水平

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The effect of acute stress on the immune system was examined in mice. Restraint stress decreasedthe number of lymphocytes in the liver, whereas the number of lymphocytes remained unchangedin the spleen and thymus. In the liver, the decrease in number appeared at 1.5 h and fell to a thirdof the control level at 3 h. The proportions of 1L-2Rβ+CD3int cells, NKT cells, CD44+ T cells andB cells were changed in the liver. The absolute numbers of IL-2Rβ+CD3int cells, NKT cells andCD3+CD44+ cells remained constant in the liver under the stress, while those of total T cells andNK cells decreased. The levels of hyaluronan (HA) in various tissues and sera were then exam-ined. The expression of hyaluronan binding protein (HARP) was found to increase in the skin, liv-er and kidney as shown by immunohistochemical staining. An increase of HA in sera due to stresswas seen at 3 h. The present results suggest that the activation of CD44+ T cells and unconven-tional cells (i.e., innate immunity) in the blood and the elevated levels of HA (ligand for CD44)in the tissues and blood are crucial responses to acute stress exposure.
机译：在小鼠中检查了急性应激对免疫系统的影响。约束应激减少了肝脏中淋巴细胞的数量，而脾脏和胸腺中的淋巴细胞数量保持不变。在肝脏中，数量的减少在1.5小时出现，并在3小时降至对照水平的三分之一。肝脏中1L-2Rβ+ CD3int细胞，NKT细胞，CD44 + T细胞和B细胞的比例发生了变化。在应激条件下，肝脏中IL-2Rβ+ CD3int细胞，NKT细胞和CD3 + CD44 +细胞的绝对数量保持恒定，而总T细胞和NK细胞的绝对数量减少。然后检查各种组织和血清中的透明质酸（HA）水平。如免疫组织化学染色所示，发现透明质酸结合蛋白（HARP）在皮肤，肝脏和肾脏中的表达增加。在3 h观察到由于压力导致的HA升高。目前的结果表明血液中CD44 + T细胞和非常规细胞的激活（即先天免疫）以及组织和血液中HA的升高水平（CD44的配体）是对急性应激暴露的关键反应。

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